Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review

• Published in: BMC neurology Vol. 16; no. 1; p. 119
• Main Authors: Nakano, Hiroro, Yanase, Daisuke, Yamada, Masahito
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.07.2016; BioMed Central
• Subjects: Aged; Analysis; Antipyrine - analogs & derivatives; Antipyrine - therapeutic use; Care and treatment; Case Report; Diffusion Magnetic Resonance Imaging - methods; Diuretics - therapeutic use; Free Radical Scavengers - therapeutic use; Furosemide - therapeutic use; Health aspects; Humans; Hyponatremia - drug therapy; Hyponatremia - etiology; Inappropriate ADH Syndrome - drug therapy; Inappropriate ADH Syndrome - etiology; Lateral medullary syndrome; Lateral Medullary Syndrome - complications; Lateral Medullary Syndrome - diagnostic imaging; Male; Neurophysiology; Pipecolic Acids - therapeutic use; Platelet Aggregation Inhibitors - therapeutic use; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Vasopressin; The paraventricular nucleus in the hypothalamus; Lateral medullary syndrome; Antidiuretic hormone; Syndrome of inappropriate secretion of antidiuretic hormone; The nucleus of the solitary tract
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-016-0641-0

Only one case of syndrome of inappropriate secretion of antidiuretic hormone with lateral medullary syndrome has been reported so far. We report a case of lateral medullary syndrome showing syndrome of inappropriate secretion of antidiuretic hormone and analyze the pathomechanism underlying its clinical features. A 67-year-old man was admitted to our hospital for dizziness, dysarthria, and dysphagia. He was diagnosed with lateral medullary syndrome based on the neurological examination and brain magnetic resonance imaging. Horner syndrome was absent. Asymptomatic hyponatremia appeared 9 days after admission and the patient was diagnosed with syndrome of inappropriate secretion of antidiuretic hormone. Fluid restriction and intravenous furosemide injection improved the hyponatremia. Lateral medullary syndrome could be associated with syndrome of inappropriate secretion of antidiuretic hormone.