The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53

• Published in: Molecular cancer research Vol. 15; no. 6; pp. 735 - 743
• Main Authors: Menendez, Daniel, Nguyen, Thuy-Ai, Snipe, Joyce, Resnick, Michael A.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.06.2017
• Subjects: APOBEC Deaminases; Cancer; Cell Line, Tumor; Cytidine Deaminase; Cytosine Deaminase - genetics; Cytosine Deaminase - metabolism; Deoxyribonucleic acid; DNA; DNA damage; Doxorubicin; Gene expression; Gene Expression Regulation - drug effects; Gene regulation; Genes; Genomes; Humans; Immune response; Immune system; Innate immunity; Interferon; Interferon Type I - pharmacology; Lymphocytes; Mutants; Mutation; Neoplasms - genetics; p53 Protein; Proteins; Transcription; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as sentinels in the innate immune response against retroviral infections and are responsive to IFN. Recently, a few A3 genes were identified as potent enzymatic sources of mutations in several human cancers. Using human cancer...