Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model

• Published in: Biomaterials Vol. 237; p. 119823
• Main Authors: Elbadawy, Mohamed, Yamanaka, Megumi, Goto, Yuta, Hayashi, Kimika, Tsunedomi, Ryouichi, Hazama, Shoichi, Nagano, Hiroaki, Yoshida, Toshinori, Shibutani, Makoto, Ichikawa, Ryo, Nakahara, Junta, Omatsu, Tsutomu, Mizutani, Tetsuya, Katayama, Yukie, Shinohara, Yuta, Abugomaa, Amira, Kaneda, Masahiro, Yamawaki, Hideyuki, Usui, Tatsuya, Sasaki, Kazuaki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2020
• Subjects: Animals; biocompatible materials; Biomarker; biomarkers; collagen; Disease Models, Animal; early diagnosis; fatty liver; gene expression; hepatoma; liver; Liver - pathology; liver cirrhosis; Liver Cirrhosis - pathology; Liver Neoplasms - pathology; Liver organoid; Mice; Mice, Inbred C57BL; NASH; Non-alcoholic Fatty Liver Disease; Organoids; pathogenesis; RNA; RNA seq, EMT, Liver fibrosis; Liver organoid; RNA seq, EMT, Liver fibrosis; Biomarker; NASH

Non-alcoholic steatohepatitis (NASH) is associated with liver fibrosis and cirrhosis, which eventually leads to hepatocellular carcinoma. Although several animal models were developed to understand the mechanisms of NASH pathogenesis and progression, it remains obscure. A 3D organoid culture system...