Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

• Published in: Nucleic acids research Vol. 33; no. 14; pp. 4544 - 4552
• Main Authors: Yonetani, Yasukazu, Hochegger, Helfrid, Sonoda, Eiichiro, Shinya, Sayoko, Yoshikawa, Hideki, Takeda, Shunichi, Yamazoe, Mistuyoshi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2005; Oxford Publishing Limited (England)
• Subjects: Animals; Camptothecin - toxicity; Cell Line; Chromatids; Chromosome Breakage; Cisplatin - toxicity; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Gene Deletion; Metazoa; Mice; Radiation, Ionizing; Recombination, Genetic

Metazoan Rad51 plays a central role in homologous DNA recombination, and its activity is controlled by a number of Rad51 cofactors. These include five Rad51 paralogs, Rad51B, Rad51C, Rad51D, XRCC2 and XRCC3. We previously hypothesized that all five paralogs participate collaboratively in repair. How...