How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?

• Published in: Laboratory investigation Vol. 102; no. 9; pp. 912 - 918
• Main Authors: Kanekura, Kohsuke, Kuroda, Masahiko
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.09.2022; Nature Publishing Group US; Nature Publishing Group
• Subjects: 14/19; 14/35; 631/80/470/2284; 692/617/375/1917/1285; 82/83; Aggregates; Alzheimer's disease; Amyotrophic Lateral Sclerosis; Dementia disorders; DNA-binding protein; Folding; Frontotemporal Dementia; FUS protein; Homogeneous mixtures; Humans; Huntingtons disease; Inclusion Bodies; Inclusions; Laboratory Medicine; Liquid phases; Liquid-solid transition; Medicine; Medicine & Public Health; Molecular modelling; Motor neuron diseases; Movement disorders; Mutation; Neurodegenerative diseases; Neurons; Parkinson's disease; Pathogenesis; Pathology; Phase separation; Phase transitions; Proteins; Review Article; Sarcoma; Superoxide Dismutase

One of the critical definitions of neurodegenerative diseases is the formation of insoluble intracellular inclusion body. These inclusions are found in various neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson'...