Lactational Exposure of Phthalate Impairs Insulin Signaling in the Cardiac Muscle of F1 Female Albino Rats

• Published in: Cardiovascular toxicology Vol. 14; no. 1; pp. 10 - 20
• Main Authors: Mangala Priya, Viswanathan, Mayilvanan, Chinnaiyan, Akilavalli, Narasimhan, Rajesh, Parsanathan, Balasubramanian, Karundevi
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2014; Springer; Springer Nature B.V
• Subjects: Age Factors; Animals; Animals, Newborn; Biomedical and Life Sciences; Biomedicine; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood sugar; Breastfeeding & lactation; Cardiology; Cardiovascular disease; Cellular signal transduction; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - chemically induced; Diethylhexyl Phthalate - toxicity; Dose-Response Relationship, Drug; Endocrine disruptors; Endocrine Disruptors - toxicity; Female; Fetuses; Glucose; Glucose Transporter Type 4 - metabolism; Heart; Insulin; Insulin - metabolism; Insulin Receptor Substrate Proteins - metabolism; Insulin resistance; Laboratories; Lactation; Metabolism; Metabolites; Myocardium - metabolism; Obesity; Oxidation; Oxidation-Reduction; Pharmacology/Toxicology; Phosphorylation; Phthalates; Plasticizers - toxicity; Polyvinyl chloride; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal transduction; Signal Transduction - drug effects; Transcription factors; Type 2 diabetes; United States > US; Type 2 diabetes; Insulin resistance; Cardiac muscle; Lactational exposure; DEHP

Di-2-ethylhexyl phthalate (DEHP), a ubiquitous endocrine disruptor and plasticizer of polyvinyl chloride, is being used in the manufacture of consumer and medical products as well as in children’s toys. Fetuses and newborns are more sensitive to endocrine disruption. DEHP is a lipophilic substance,...