Persistence of HIV-1 Transmitted Drug Resistance Mutations
There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent t...
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Published in | The Journal of infectious diseases Vol. 208; no. 9; pp. 1459 - 1463 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Oxford
Oxford University Press
01.11.2013
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Abstract | There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models. |
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AbstractList | There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models. |
Author | Castro, Hannah Phillips, Andrew Pillay, Deenan Cane, Patricia Asboe, David Dunn, David T. Cambiano, Valentina |
AuthorAffiliation | 3 Virus Reference Department , Public Health England , London , United Kingdom 5 Research Department of Infection and Population Health , University College London , London , United Kingdom 1 Medical Research Council Clinical Trials Unit , London , United Kingdom 2 Division of Infection and Immunity , University College London , London , United Kingdom 4 Directorate of HIV Medicine and Sexual Health , Chelsea and Westminster Hospital , London , United Kingdom |
AuthorAffiliation_xml | – name: 4 Directorate of HIV Medicine and Sexual Health , Chelsea and Westminster Hospital , London , United Kingdom – name: 2 Division of Infection and Immunity , University College London , London , United Kingdom – name: 1 Medical Research Council Clinical Trials Unit , London , United Kingdom – name: 5 Research Department of Infection and Population Health , University College London , London , United Kingdom – name: 3 Virus Reference Department , Public Health England , London , United Kingdom |
Author_xml | – sequence: 1 givenname: Hannah surname: Castro fullname: Castro, Hannah – sequence: 2 givenname: Deenan surname: Pillay fullname: Pillay, Deenan – sequence: 3 givenname: Patricia surname: Cane fullname: Cane, Patricia – sequence: 4 givenname: David surname: Asboe fullname: Asboe, David – sequence: 5 givenname: Valentina surname: Cambiano fullname: Cambiano, Valentina – sequence: 6 givenname: Andrew surname: Phillips fullname: Phillips, Andrew – sequence: 7 givenname: David T. surname: Dunn fullname: Dunn, David T. |
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ContentType | Journal Article |
Contributor | Kaye, Steve Hale, Tony Tandy, Richard Greatorex, Jane Rice, Philip Tilston, Peter Smit, Erasmus Hué, Stéphane Pillay, Deenan Cane, Patricia Webster, Daniel Orkin, Chloe Ashton, Lynn Churchill, Duncan Clark, Duncan Kirk, Stuart Templeton, Kate Hay, Phillip Rice, Phillip Collins, Simon Mackie, Nicola Castro, Hannah Payne, Brendan Leigh-Brown, Andrew Delpech, Valerie Goldberg, David Wildfire, Adrian Zhang, Hongyi Chadwick, David Tong, William Geretti, Anna Maria Lazarus, Linda Hale, Antony Bibby, David Aitken, Celia Cox, Alison Mbisa, Tamyo Schmid, Matthias L Asboe, David Williams, Ian Gunson, Rory Paynter, Mary Shepherd, Jill Hopkins, Mark Zuckerman, Mark Fawcett, Tracy Kellam, Paul O'Shea, Siobhan Garcia-Diaz, Ana Mullen, Jane Maclean, Alasdair |
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Copyright | Copyright © 2013 Oxford University Press on behalf of the Infectious Diseases Society of America 2014 INIST-CNRS The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. 2013 |
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Keywords | Virus Infection Resistance HIV-1 virus Retroviridae Human immunodeficiency virus Mutation Lentivirus HIV-1 persistence mutations transmitted resistance |
Language | English |
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SubjectTerms | Adolescent Adult Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Biological and medical sciences Drug resistance Drug Resistance, Viral - genetics Female Fundamental and applied biological sciences. Psychology Genetic mutation HIV HIV 1 HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV/AIDS Hospital units Human immunodeficiency virus 1 Humans Infections Infectious diseases Major and Brief Reports Male Medical sciences Memory interference Microbiology Miscellaneous Teaching hospitals Virology Viruses Young Adult |
Title | Persistence of HIV-1 Transmitted Drug Resistance Mutations |
URI | https://www.jstor.org/stable/42580592 https://www.ncbi.nlm.nih.gov/pubmed/23904291 https://search.proquest.com/docview/1443385183 https://search.proquest.com/docview/1654689367 https://pubmed.ncbi.nlm.nih.gov/PMC3789571 |
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