Improvement of Neutral Lipid and Polyunsaturated Fatty Acid Biosynthesis by Overexpressing a Type 2 Diacylglycerol Acyltransferase in Marine Diatom Phaeodactylum tricornutum

• Published in: Marine drugs Vol. 11; no. 11; pp. 4558 - 4569
• Main Authors: Niu, Ying-Fang, Zhang, Meng-Han, Li, Da-Wei, Yang, Wei-Dong, Liu, Jie-Sheng, Bai, Wei-Bin, Li, Hong-Ye
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.11.2013; MDPI
• Subjects: Acid production; Amino Acid Sequence; Bioactive compounds; Biochemistry; Biosynthesis; Cloning, Molecular - methods; diacylglycerol acyltranferase; Diacylglycerol O-Acyltransferase - genetics; diatom; Diatoms - enzymology; Diatoms - genetics; Diatoms - metabolism; Fatty Acids - genetics; Fatty Acids - metabolism; Fatty Acids, Unsaturated - biosynthesis; Lipids - biosynthesis; Microalgae; Molecular Sequence Data; neutral lipid; Photosynthesis - genetics; Polyunsaturated fatty acids; PUFA

Microalgae have been emerging as an important source for the production of bioactive compounds. Marine diatoms can store high amounts of lipid and grow quite quickly. However, the genetic and biochemical characteristics of fatty acid biosynthesis in diatoms remain unclear. Glycerophospholipids are i...