Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Crypto...

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Published inRevista do Instituto de Medicina Tropical de São Paulo Vol. 59; pp. e76 - 3
Main Authors Cáceres, Diego H, Zuluaga, Alejandra, Tabares, Ángela M, Chiller, Tom, González, Ángel, Gómez, Beatriz L
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Instituto de Medicina Tropical de Sao Paulo 21.12.2017
Instituto de Medicina Tropical
Universidade de São Paulo (USP)
Subjects
Antigen
Brief Communication
Cryptococcosis
Cryptococcus
Diagnosis
Immunochromatographic assay
Lateral Flow Assay
Latex agglutination system
Point-of-care
TROPICAL MEDICINE
Antigen
Cryptococcosis
Lateral Flow Assay
Immunochromatographic assay
Cryptococcus
Latex agglutination system
Diagnosis
Point-of-care
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Summary:A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.
Bibliography:ObjectType-Article-1
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CONFLICT OF INTERESTS
The authors report no conflict of interests.
ISSN:1678-9946
0036-4665
1678-9946
DOI:10.1590/S1678-9946201759076