Biology and therapy of inherited retinal degenerative disease: insights from mouse models

• Published in: Disease models & mechanisms Vol. 8; no. 2; pp. 109 - 129
• Main Authors: Veleri, Shobi, Lazar, Csilla H., Chang, Bo, Sieving, Paul A., Banin, Eyal, Swaroop, Anand
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.02.2015; The Company of Biologists Limited; The Company of Biologists
• Subjects: Animals; Disease; Disease Models, Animal; Genes; Genetic Diseases, Inborn - therapy; Humans; Light Signal Transduction; Macular degeneration; Mice; Mouse mutants; Mutation; Photoreceptor; Photoreceptor Cells, Vertebrate - pathology; Photoreceptors; Proteins; Retina; Retina - pathology; Retina - physiopathology; Retinal Degeneration - therapy; Retinal development; Retinal disease; Review; Retinal development; Mouse mutants; Retinal disease; Photoreceptor

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a major cause of incurable vision loss. Tremendous progress has been made over the last two decades in discovering genes and genetic defects that lead to retinal diseases. The primary focus has now shifted to unc...