Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone

• Published in: Diabetes research and clinical practice Vol. 76; no. 1; pp. 12 - 17
• Main Authors: Suzuki, Masaaki, Takamisawa, Itaru, Yoshimasa, Yasunao, Harano, Yutaka
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.04.2007
• Subjects: Adult; Aged; Blood Glucose - drug effects; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Endocrinology & Metabolism; Endothelial dysfunction; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - therapeutic use; Insulin - blood; Insulin Resistance; Male; Nitroglycerin - analogs & derivatives; Nitroglycerin - pharmacology; Pioglitazone; Thiazolidinediones - administration & dosage; Thiazolidinediones - therapeutic use; Vasodilation - drug effects; Endothelial dysfunction; Insulin resistance; Pioglitazone
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2006.07.033

Endothelial dysfunction is regarded as an early stage of atherosclerosis, and plays a role in the development of atherosclerotic diseases. Insulin resistance is related to the atherosclerotic process. In this study, we examined the association between endothelial function and insulin resistance in 48 subjects with type 2 diabetes. In addition, the effects of pioglitazone treatment on endothelial function and insulin resistance were investigated in a subgroup of subjects. Endothelial function of the brachial artery was non-invasively assessed using ultrasound technique. We measured flow-mediated endothelium-dependent vasodilation (FMD) and glyceryl trinitrate-induced endothelium-independent vasodilation (GTN). Insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. High SSPG levels indicate insulin resistance. There was a significant inverse correlation ( r = −0.462, p < 0.001) between SSPG and FMD. Systolic blood pressure was inversely correlated with FMD ( r = −0.360, p < 0.013). By multiple regression analysis, insulin resistance was the sole predictor of FMD. The effects of chronic treatment with pioglitazone were assessed in 10 subjects with type 2 diabetes. The increase in FMD significantly correlated with the decrease in SSPG. There is a significant association between vascular endothelial dysfunction and insulin resistance in type 2 diabetes. This result was supported by the effects of the insulin sensitizer, pioglitazone.