Adjuvanted Intranasal Norwalk Virus-Like Particle Vaccine Elicits Antibodies and Antibody-Secreting Cells That Express Homing Receptors for Mucosal and Peripheral Lymphoid Tissues

• Published in: The Journal of infectious diseases Vol. 202; no. 11; pp. 1649 - 1658
• Main Authors: El-Kamary, Samer S., Pasetti, Marcela F., Mendelman, Paul M., Frey, Sharon E., Bernstein, David I., Treanor, John J., Ferreira, Jennifer, Chen, Wilbur H., Sublett, Richard, Richardson, Charles, Bargatze, Robert F., Sztein, Marcelo B., Tacket, Carol O.
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 01.12.2010; University of Chicago Press; Oxford University Press
• Subjects: Adjuvants, Immunologic - administration & dosage; Administration, Intranasal; Adolescent; Adult; Antibodies; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Antibody-Producing Cells - immunology; Antibody-Producing Cells - metabolism; Antigens; Applied microbiology; Biological and medical sciences; Caliciviridae Infections - prevention & control; Caliciviridae Infections - virology; Chitosan - administration & dosage; Chitosan - immunology; Dosage; Double-Blind Method; Fundamental and applied biological sciences. Psychology; Gastroenteritis - prevention & control; Gastroenteritis - virology; Geometric mean; Hemagglutination Inhibition Tests; Homing; Humans; Immunoglobulins; Infectious diseases; Integrins; Lipid A - administration & dosage; Lipid A - analogs & derivatives; Lipid A - immunology; Lymphoid Tissue - metabolism; Lymphoid Tissue - virology; Major and Brief Reports; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Mucous Membrane - metabolism; Mucous Membrane - virology; Norovirus; Norwalk virus; Norwalk virus - immunology; Receptors, Lymphocyte Homing - metabolism; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral Vaccines - administration & dosage; Viral Vaccines - adverse effects; Viral Vaccines - immunology; Viral Vaccines - standards; Virology; Viruses; Young Adult; Virus; Infection; Calicivirus; Antibody; Norwalk like virus; Caliciviridae; Immunological adjuvant; Mucosa; Virus like particle; Vaccine; Intranasal administration; Lymphoid tissue

Background. Noroviruses cause significant morbidity and mortality from acute gastroenteritis in all age groups worldwide. Methods.We conducted 2 phase 1 double-blind, controlled studies of a virus-like particle (VLP) vaccine derived from norovirus GI.1 genotype adjuvanted with monophosphoryl lipid A...