Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study - Lamarre-Cliche, Maxime; Souich, Patrick du; Champlain, Jacques de; Larochelle, Pierre (Clinical therapeutics, 2008)
Keywords: Adult; Autonomic Nervous System - drug effects; Biological and medical sciences; Blood Pressure - drug effects; Catecholamines; Chromatography, High Pressure Liquid; Cross-Over Studies; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Dopamine; Drug dosages; drug therapy; Fainting; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Heart attacks; Heart rate; Heart Rate - drug effects; Humans; Hypertension; Hypotension, Orthostatic - drug therapy; Internal Medicine; Male; Medical Education; Medical sciences; Menstruation; midodrine; Midodrine - administration & dosage; Midodrine - pharmacokinetics; Midodrine - pharmacology; Midodrine - therapeutic use; Natriuretic Peptides - blood; Natriuretic Peptides - pharmacology; Natriuretic Peptides - therapeutic use; Nervous system; Nervous system (semeiology, syndromes); neurocardiogenic syncope; Neurology; Norepinephrine - blood; Orthostatic hypotension; Peptides; Pharmacokinetics; Pharmacology. Drug treatments; Plasma; Prospective Studies; Single-Blind Method; Sympathomimetics - administration & dosage; Sympathomimetics - pharmacokinetics; Sympathomimetics - pharmacology; Sympathomimetics - therapeutic use; Syncope, Vasovagal - drug therapy; Canada; Quebec Canada; orthostatic hypotension; drug therapy; neurocardiogenic syncope; midodrine; Biological fluid; Pharmacokinetic pharmacodynamic relationship; Agonist; Vasodilator agent; Pharmacotherapy; Cardiovascular disease; Atrial natriuretic peptide; Blood plasma; Prospective; Postural hypotension; Randomization; Natriuretic hormone; Syncope; Autonomic nervous system; Arterial pressure; Blood pressure; Neurological disorder; Nervous system diseases; Consciousness impairment; Sympathomimetic; Midodrine; Crossover study; Treatment; Arterial hypotension; Diseases of the autonomic nervous system; Placebo; Antihypertensive agent; Hemodynamics