Differences in Cytokine Production in Human Macrophages and in Virulence in Mice Are Attributable to the Acidic Polymerase Protein of Highly Pathogenic Influenza A Virus Subtype H5N1

• Published in: The Journal of infectious diseases Vol. 207; no. 2; pp. 262 - 271
• Main Authors: Sakabe, Saori, Takano, Ryo, Nagamura-Inoue, Tokiko, Yamashita, Naohide, Nidom, Chairul A., Mai thi Quynh Le, Iwatsuki-Horimoto, Kiyoko, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.01.2013
• Series: Editor's choice
• Subjects: Animals; Biological and medical sciences; Cytokines; Cytokines - biosynthesis; Cytokines - immunology; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - virology; Female; Fundamental and applied biological sciences. Psychology; Genes; H5N1 subtype influenza A virus; HEK293 Cells; Human growth; Humans; Infections; Infectious diseases; Influenza; Influenza A virus; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza A Virus, H5N1 Subtype - physiology; Influenza, Human - immunology; Influenza, Human - virology; Macrophages; Macrophages - immunology; Macrophages - virology; Madin Darby Canine Kidney Cells; Major and Brief Reports; Medical sciences; Mice; Mice, Inbred BALB C; Microbiology; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; Reassortant Viruses - genetics; Reassortant Viruses - metabolism; Reassortant Viruses - pathogenicity; RNA Replicase - genetics; Viral Proteins - genetics; Virulence; Virulence - genetics; Viruses; Human; Infection; Influenzavirus A(H5N1); Vertebrata; Mammalia; Mouse; Acidic protein; Virulence; Rodentia; Cytokine; Subtype; Macrophage

Background. The pathogenesis of influenza A virus subtype H5N1 (hereafter, "H5N1") infection in humans is not completely understood, although hypercytokinemia is thought to play a role. We previously reported that most H5N1 viruses induce high cytokine responses in human macrophages, where...