Navy Bean Supplementation in Established High-Fat Diet-Induced Obesity Attenuates the Severity of the Obese Inflammatory Phenotype

• Published in: Nutrients Vol. 13; no. 3; p. 757
• Main Authors: Monk, Jennifer M, Wu, Wenqing, Lepp, Dion, Pauls, K Peter, Robinson, Lindsay E, Power, Krista A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.02.2021; MDPI
• Subjects: Adipose tissue; Adipose Tissue - metabolism; adipose tissue inflammation; Animals; Beans; Biomarkers - metabolism; Body weight; Body Weight - drug effects; Body weight loss; caloric restriction; Chemokines; Colon; Cytokines; Diabetes; Diet; Diet, High-Fat - adverse effects; Diet, High-Fat - methods; Diet, Reducing - methods; Dietary fiber; Dietary Supplements; Dysbacteriosis; epithelial barrier; Feces; Feces - microbiology; Gastrointestinal Microbiome; Genotype & phenotype; Haricot beans; High fat diet; Hormones; Inflammation; Interleukin 6; intestinal health; Intestinal Mucosa - metabolism; Intestine; Leptin; Loss control; Low fat diet; Male; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Mice, Obese; Microbiomes; Microbiota; Monocyte chemoattractant protein 1; navy beans; NF-κB protein; Obesity; Obesity - diet therapy; Obesity - metabolism; Permeability; Phaseolus; Phaseolus vulgaris; Phenotype; Phenotypes; Powders; Protein expression; Proteins; Severity of Illness Index; Software; Stat3 protein; Vegetables; Weight control; Weight loss; Weight reduction; Zonula occludens-1 protein; Canada; United States > US; navy beans; caloric restriction; intestinal health; epithelial barrier; adipose tissue inflammation; obesity

Cooked common beans ( ) improve intestinal health in lean mice and attenuate intestinal dysbiosis and inflammation when consumed concurrent with obesity development. We determined the effects of a high-fat (HF) bean supplemented diet in mice with established obesity (induced by 12 weeks of HF diet (...