Decellularized tissue engineered hyaline cartilage graft for articular cartilage repair

• Published in: Biomaterials Vol. 235; p. 119821
• Main Authors: Nie, Xiaolei, Chuah, Yon Jin, Zhu, Wenzhen, He, Pengfei, Peck, Yvonne, Wang, Dong-An
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2020
• Subjects: Animals; biocompatible materials; Cartilage; Cartilage, Articular; Chondrocytes; Decellularization; DNA microarrays; histology; Hyaline Cartilage; Knee Joint; Large animal model; microstructure; orthopedics; phenotype; Pre-clinical; Scaffold-free; Swine; Tissue Engineering; Transplantation, Autologous; Pre-clinical; Cartilage; Large animal model; Scaffold-free; Tissue engineering; Decellularization

Articular cartilage repair has been a long-standing challenge in orthopaedic medicine due to the limited self-regenerative capability of cartilage tissue. Currently, cartilage lesions are often treated by microfracture or autologous chondrocyte implantation (ACI). However, these treatments are frequ...