The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes

• Published in: Atherosclerosis Vol. 197; no. 2; pp. 883 - 888
• Main Authors: Simonen, Piia, Gylling, Helena, Miettinen, Tatu A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2008; Elsevier
• Subjects: Adult; Aged; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Cholestanol; Cholesterol - blood; Cholesterol - metabolism; Cholesterol absorption; Cholesterol synthesis; Chromatography, Gas; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Lathosterol; Male; Medical sciences; Middle Aged; Phytosterols - blood; Sitosterol; Squalene; Squalene - blood; Type 2 diabetes; Type 2 diabetes; Sitosterol; Cholestanol; Squalene; Lathosterol; Cholesterol synthesis; Cholesterol absorption; Endocrinopathy; Lipids; Metabolic diseases; Cardiovascular disease; Cholesterol; Vascular disease; Atherosclerosis; Sterol

Abstract Objective Serum non-cholesterol sterol ratios to cholesterol reflect cholesterol metabolism in non-diabetes populations. In type 2 diabetes (T2D) cholesterol metabolism is perturbed, and the role of squalene and non-cholesterol sterols has not been related to absolute cholesterol metabolism...