Ingestion of Exopolymers from Aureobasidium pullulans Reduces the Duration of Cold and Flu Symptoms: A Randomized, Placebo-Controlled Intervention Study

Aim. The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults. Methods. We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (3...

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Published inEvidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 12
Main Authors Choi, Jae-Suk, Baek, Kyung Min, Lee, Seo-Young, Cho, Hyung-Rae, Jung, Go-Woon, Park, Dong-Chan, Do, Eunju, Lim, Jong Min, Shin, Jae Wook
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Subjects
Adults
Antigens
Aureobasidium pullulans
Blood cell count
Cellulose
Colds
Cytokines
Dietary supplements
Double-blind studies
Drug dosages
Experiments
Food
Functional foods
Functional foods & nutraceuticals
Immune system
Infections
Influenza
Medical research
Nutrition
Older people
Pathogens
Pleurotus ostreatus
Severe acute respiratory syndrome
Statistical analysis
Viral infections
South Korea
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Abstract Aim. The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults. Methods. We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30–70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated. Results. EAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed. Conclusion. The results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.
AbstractList The objective of the study was to assess the efficacy of exopolymers from (EAP) on the incidence of colds and flu in healthy adults. We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30-70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated. EAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed. The results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.
Aim. The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults. Methods. We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30-70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated. Results. EAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed. Conclusion. The results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.
Aim . The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults. Methods . We conducted a randomized, double‐blind, placebo‐controlled study at the onset of the influenza season. A total of 76 subjects (30–70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated. Results . EAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed. Conclusion . The results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.
The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults.AIMThe objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults.We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30-70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated.METHODSWe conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30-70 years of age) were recruited from the general population. The subjects were instructed to take one capsule per day of either EAP or a placebo for a period of 8 weeks. The duration of cold and flu symptoms, a primary variable in assessing effectiveness, and serum cytokine levels as well as WBC counts as secondary variables were also evaluated.EAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed.RESULTSEAP was associated with a statistically significant decrease in the duration of cold and flu symptoms, a primary variable in assessing effectiveness. Although cold and flu symptom levels were not significantly different at a significance level of 5%, the cold and flu symptom levels of the EAP group were less severe compared to the placebo group. No statistically significant changes of serum cytokine levels as well as WBC counts were observed.The results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.CONCLUSIONThe results showed that EAP is a useful pharmaceutical and functional food material for preventing and treating colds and flu.
Audience Academic
Author Lee, Seo-Young
Baek, Kyung Min
Jung, Go-Woon
Park, Dong-Chan
Choi, Jae-Suk
Do, Eunju
Cho, Hyung-Rae
Lim, Jong Min
Shin, Jae Wook
AuthorAffiliation 4 Major in Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University, 140, Baegyang-daero 700beon-gil, Sasang-gu, Busan 46958, Republic of Korea
1 Glucan Corp., #305 Marine Bio-Industry Development Center, 7 Hoenggye-gil, Ilgwang-myeon, Busan 46048, Republic of Korea
3 Department of Korean Medicine for Internal Medicine, Daegu Korean Medicine Hospital of Daegu Haany University, 136 Sincheondong-ro, Suseong-gu, Daegu 42158, Republic of Korea
2 Korean Medicine Industry Support Center, Daegu Technopark, 136 Sincheondong-ro, Suseong-gu, Daegu 42158, Republic of Korea
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30002717$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2018 Jong-Min Lim et al.
COPYRIGHT 2018 John Wiley & Sons, Inc.
Copyright © 2018 Jong-Min Lim et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2018 Jong-Min Lim et al. 2018
Copyright_xml – notice: Copyright © 2018 Jong-Min Lim et al.
– notice: COPYRIGHT 2018 John Wiley & Sons, Inc.
– notice: Copyright © 2018 Jong-Min Lim et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2018 Jong-Min Lim et al. 2018
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Snippet Aim. The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy...
Aim . The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy...
The objective of the study was to assess the efficacy of exopolymers from (EAP) on the incidence of colds and flu in healthy adults. We conducted a randomized,...
The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy...
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StartPage 1
SubjectTerms Adults
Antigens
Aureobasidium pullulans
Blood cell count
Cellulose
Colds
Cytokines
Dietary supplements
Double-blind studies
Drug dosages
Experiments
Food
Functional foods
Functional foods & nutraceuticals
Immune system
Infections
Influenza
Medical research
Nutrition
Older people
Pathogens
Pleurotus ostreatus
Severe acute respiratory syndrome
Statistical analysis
Viral infections
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Title Ingestion of Exopolymers from Aureobasidium pullulans Reduces the Duration of Cold and Flu Symptoms: A Randomized, Placebo-Controlled Intervention Study
URI https://search.emarefa.net/detail/BIM-1156790
https://dx.doi.org/10.1155/2018/9024295
https://www.ncbi.nlm.nih.gov/pubmed/30002717
https://www.proquest.com/docview/2052740795
https://www.proquest.com/docview/2070241181
https://pubmed.ncbi.nlm.nih.gov/PMC5998159
Volume 2018
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