Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

• Published in: Biomaterials Vol. 268; p. 120546
• Main Authors: Zhou, Wenxi, Zhou, Yu, Chen, Xinli, Ning, Tingting, Chen, Hongyi, Guo, Qin, Zhang, Yiwen, Liu, Peixin, Zhang, Yujie, Li, Chao, Chu, Yongchao, Sun, Tao, Jiang, Chen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2021
• Subjects: adenocarcinoma; biocompatible materials; BM-MSC exosomes; bone marrow; cancer therapy; cell death; cytotoxicity; drug therapy; drugs; exosomes; Galectin 9/dectin 1 axis; galectins; Immunogenic cell death; immunogenicity; immunosuppression; immunotherapy; Macrophage polarization; macrophages; mesenchymal stromal cells; Pancreatic cancer immunotherapy; Galectin 9/dectin 1 axis; Macrophage polarization; Pancreatic cancer immunotherapy; Immunogenic cell death; BM-MSC exosomes

Immunotherapy has gained increasing focus in treating pancreatic ductal adenocarcinoma (PDAC), since conventional therapies like chemotherapy could not provide satisfactory improvement in overall survival outcome of PDAC patients. However, it is still not the game changing solution due to the unique...