Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
Dongxin Lin and colleagues report a genome-wide association study for pancreatic cancer in Chinese populations. The authors identify five new genetic loci associated with risk of pancreatic cancer. Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers...
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| Published in | Nature genetics Vol. 44; no. 1; pp. 62 - 66 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.01.2012
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Dongxin Lin and colleagues report a genome-wide association study for pancreatic cancer in Chinese populations. The authors identify five new genetic loci associated with risk of pancreatic cancer.
Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (
P
= 2.24 × 10
−13
to
P
= 4.18 × 10
−10
) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. |
|---|---|
| AbstractList | Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 x 10 super(-13) to P = 4.18 x 10 super(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10^sup -13^ to P = 4.18 × 10^sup -10^) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. [PUBLICATION ABSTRACT] Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21 q21.3, 5p13.1, 21 q22.3, 22q13.32 and 10q26.11 (P = 2.24 x [10.sup.-13] to P = 4.18 x [10.sup.-10]) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. Dongxin Lin and colleagues report a genome-wide association study for pancreatic cancer in Chinese populations. The authors identify five new genetic loci associated with risk of pancreatic cancer. Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 ( P = 2.24 × 10 −13 to P = 4.18 × 10 −10 ) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. |
| Audience | Academic |
| Author | Cheung, Siu Tim Zhao, Ping Jiang, Guoliang Yu, Xianjun Jia, Yongfeng Hu, Zhibin Xu, Jian Miao, Xiaoping Li, Zhaoshen Dai, Wanjin Che, Xu Zhang, Xianghong Gao, Jun Shen, Hongbing Yu, Dianke Wu, Chen Wang, Xiaoqi Zhou, Yongjian Cao, Guangwen Huang, Liming Wang, Chengfeng Zhou, Yifeng Zhai, Kan Chen, Yanling Liu, Yu Wang, Chunyou Lin, Dongxin Cao, Wei Zhang, Sheng Ma, Ying Sun, Menghong Yang, Xianghong Liu, Luming Wu, Tangchun Zheng, Xiongwei Tan, Wen Zuo, Chaohui Chang, Jiang |
| Author_xml | – sequence: 1 givenname: Chen surname: Wu fullname: Wu, Chen organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 2 givenname: Xiaoping surname: Miao fullname: Miao, Xiaoping organization: Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology – sequence: 3 givenname: Liming surname: Huang fullname: Huang, Liming organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 4 givenname: Xu surname: Che fullname: Che, Xu organization: Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 5 givenname: Guoliang surname: Jiang fullname: Jiang, Guoliang organization: Department of Radiation Oncology, Cancer Hospital, Fudan University – sequence: 6 givenname: Dianke surname: Yu fullname: Yu, Dianke organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 7 givenname: Xianghong surname: Yang fullname: Yang, Xianghong organization: Department of Pathology, Shengjing Hospital, China Medical University – sequence: 8 givenname: Guangwen surname: Cao fullname: Cao, Guangwen organization: Department of Epidemiology, Second Military Medical University – sequence: 9 givenname: Zhibin surname: Hu fullname: Hu, Zhibin organization: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University – sequence: 10 givenname: Yongjian surname: Zhou fullname: Zhou, Yongjian organization: Department of Gastrointestinal Surgery, Union Hospital of Fujian Medical University – sequence: 11 givenname: Chaohui surname: Zuo fullname: Zuo, Chaohui organization: Department of Gastroduodenal and Pancreatic Surgery, Hunan Province Tumor Hospital – sequence: 12 givenname: Chunyou surname: Wang fullname: Wang, Chunyou organization: Union Hospital, Tongji Medical College, Huazhong University of Sciences and Technology – sequence: 13 givenname: Xianghong surname: Zhang fullname: Zhang, Xianghong organization: Department of Experimental Pathology, Hebei Medical University – sequence: 14 givenname: Yifeng surname: Zhou fullname: Zhou, Yifeng organization: Laboratory of Cancer Molecular Genetics, Medical College of Soochow University – sequence: 15 givenname: Xianjun surname: Yu fullname: Yu, Xianjun organization: Department of Pancreas and Hepatobiliary Surgery, Cancer Hospital, Fudan University – sequence: 16 givenname: Wanjin surname: Dai fullname: Dai, Wanjin organization: Department of Pathology, Shengjing Hospital, China Medical University – sequence: 17 givenname: Zhaoshen surname: Li fullname: Li, Zhaoshen organization: Department of Gastroenterology, First Affiliated Hospital, Second Military Medical University – sequence: 18 givenname: Hongbing surname: Shen fullname: Shen, Hongbing organization: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University – sequence: 19 givenname: Luming surname: Liu fullname: Liu, Luming organization: Department of Integrative Oncology, Cancer Hospital, Fudan University – sequence: 20 givenname: Yanling surname: Chen fullname: Chen, Yanling organization: Department of Hepatobiliary and Pancreatic Surgery, Union Hospital of Fujian Medical University – sequence: 21 givenname: Sheng surname: Zhang fullname: Zhang, Sheng organization: Department of Pathology, First Affiliated Hospital of Fujian Medical University – sequence: 22 givenname: Xiaoqi surname: Wang fullname: Wang, Xiaoqi organization: Department of Surgery, The University of Hong Kong – sequence: 23 givenname: Kan surname: Zhai fullname: Zhai, Kan organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 24 givenname: Jiang surname: Chang fullname: Chang, Jiang organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 25 givenname: Yu surname: Liu fullname: Liu, Yu organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 26 givenname: Menghong surname: Sun fullname: Sun, Menghong organization: Department of Pathology, Cancer Hospital, Fudan University – sequence: 27 givenname: Wei surname: Cao fullname: Cao, Wei organization: Department of Pathology, Shengjing Hospital, China Medical University – sequence: 28 givenname: Jun surname: Gao fullname: Gao, Jun organization: Department of Gastroenterology, First Affiliated Hospital, Second Military Medical University – sequence: 29 givenname: Ying surname: Ma fullname: Ma, Ying organization: Department of Pathology, Shengjing Hospital, China Medical University – sequence: 30 givenname: Xiongwei surname: Zheng fullname: Zheng, Xiongwei organization: Department of Pathology, Fujian Provincial Cancer Hospital – sequence: 31 givenname: Siu Tim surname: Cheung fullname: Cheung, Siu Tim organization: Department of Surgery, The University of Hong Kong – sequence: 32 givenname: Yongfeng surname: Jia fullname: Jia, Yongfeng organization: Department of Pathology, Affiliated Hospital, Inner Mongolia School of Medicine – sequence: 33 givenname: Jian surname: Xu fullname: Xu, Jian organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 34 givenname: Wen surname: Tan fullname: Tan, Wen organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 35 givenname: Ping surname: Zhao fullname: Zhao, Ping organization: Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 36 givenname: Tangchun surname: Wu fullname: Wu, Tangchun organization: Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology – sequence: 37 givenname: Chengfeng surname: Wang fullname: Wang, Chengfeng email: wangcf369@medmail.com organization: Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College – sequence: 38 givenname: Dongxin surname: Lin fullname: Lin, Dongxin email: lindx72@cicams.ac.cn organization: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25661656$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22158540$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2011 2015 INIST-CNRS COPYRIGHT 2012 Nature Publishing Group Copyright Nature Publishing Group Jan 2012 |
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| Keywords | Pancreas cancer Digestive diseases Chinese Identification Malignant tumor Locus Cancer Pancreatic disease |
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| Snippet | Dongxin Lin and colleagues report a genome-wide association study for pancreatic cancer in Chinese populations. The authors identify five new genetic loci... Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify... |
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| SubjectTerms | 631/208/205/2138 631/208/727/2000 631/67/2324 692/699/67/1504/1713 Agriculture Animal Genetics and Genomics Asian Continental Ancestry Group - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Chromosomes Confidence intervals Disease susceptibility Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Function Genealogy Genetic aspects Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Genotype Human Genetics Humans Kinases letter Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mutation Pancreas Pancreatic cancer Pancreatic Neoplasms - genetics Polymorphism, Single Nucleotide Risk assessment Risk factors Single nucleotide polymorphisms Survival Tumors |
| Title | Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations |
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