Biogenesis and secretion of exosomes

• Published in: Current opinion in cell biology Vol. 29; pp. 116 - 125
• Main Authors: Kowal, Joanna, Tkach, Mercedes, Théry, Clotilde
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2014; Elsevier
• Subjects: Animals; Biological Transport; Cell Membrane - metabolism; Exosomes - secretion; Humans; Internal Medicine; Life Sciences

•ESCRT proteins, lipids and tetraspanins can independently generate intraluminal vesicles.•Different RAB proteins can target multivesicular compartments to the plasma membrane.•Vesicles with different densities, and probably different origins, are co-secreted. Although observed for several decades,...