Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum

• Published in: Clinical cancer research Vol. 23; no. 8; pp. 1998 - 2005
• Main Authors: Hulbert, Alicia, Jusue-Torres, Ignacio, Stark, Alejandro, Chen, Chen, Rodgers, Kristen, Lee, Beverly, Griffin, Candace, Yang, Andrew, Huang, Peng, Wrangle, John, Belinsky, Steven A., Wang, Tza-Huei, Yang, Stephen C., Baylin, Stephen B., Brock, Malcolm V., Herman, James G.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 15.04.2017
• Subjects: Aged; Area Under Curve; Beads; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Cancer; Cancer screening; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - genetics; Case-Control Studies; Computed tomography; Confidence intervals; Deoxyribonucleic acid; Diagnostic systems; DNA; DNA - analysis; DNA methylation; DNA Methylation - genetics; Early Detection of Cancer - methods; Experimental design; Female; Gene Expression Profiling - methods; Genes; Humans; Lung cancer; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Male; Medical screening; Middle Aged; Nodules; Plasma; Prediction models; Promoter Regions, Genetic - genetics; Real-Time Polymerase Chain Reaction; ROC Curve; Sensitivity; Sensitivity and Specificity; Sputum; Sputum - chemistry; Transcriptome

Purpose: CT screening can reduce death from lung cancer. We sought to improve the diagnostic accuracy of lung cancer screening using ultrasensitive methods and a lung cancer–specific gene panel to detect DNA methylation in sputum and plasma. Experimental Design: This is a case–control study of subje...