The effect of early goal-directed therapy for treatment of severe sepsis or septic shock: a systemic review and meta-analysis

• Published in: Journal of critical care Vol. 38; pp. 115 - 122
• Main Authors: Park, Sun-Kyung, MD, Shin, Su Rin, MD, Hur, Min, MD, Kim, Won Ho, MD,PhD, Oh, Eun-Ah, MD, Soo, Hee Lee, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017; Elsevier Limited
• Subjects: Antibiotics; Bias; Critical Care; Critical Pathways; Goal-directed therapy; Handbooks; Humans; Meta-analysis; Mortality; Resuscitation - methods; Sepsis; Sepsis - mortality; Sepsis - therapy; Shock, Septic - mortality; Shock, Septic - therapy; Short term; Studies; United Kingdom > UK; Australia; United States > US; meta-analysis; mortality; goal-directed therapy; sepsis; Goal-directed therapy; Sepsis; Mortality; Meta-analysis

Abstract Purpose To assess the effects of early goal directed therapy (EGDT) on reducing mortality compared to conventional management of severe sepsis or septic shock. Materials and Methods We included a systemic review, using the Medline and EMBASE. Seventeen randomized trials with 5765 patients c...