Argonaute 5-mediated antiviral defense and viral counter-defense in Nicotiana benthamiana

• Published in: Virus research Vol. 334; p. 199179
• Main Authors: Tu, Chin-Wei, Huang, Ying-Wen, Lee, Chin-Wei, Kuo, Song-Yi, Lin, Na-Sheng, Hsu, Yau-Heiu, Hu, Chung-Chi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2023; Elsevier
• Subjects: 26S proteasome; AGO5; Antiviral Agents - metabolism; Autophagy; Cucumovirus - genetics; Cytomegalovirus Infections; Nicotiana; Plant antiviral defense; Plant Diseases; RNA - metabolism; RNA Interference; RNA silencing; Viral suppressors of RNA silencing (VSR); Viral suppressors of RNA silencing (VSR); AGO5; 26S proteasome; RNA silencing; Plant antiviral defense; Autophagy

•NbAGO5 expression is ubiquitously stimulated upon viral infections.•NbAGO5 confers defense against diverse viruses by binding to vsiRNAs.•CMV and TuMV counteract plant defense by degrading NbAGO5 protein.•CMV 2b and TuMV HC-Pro drive NbAGO5 degradation by 26S proteasome and autophagy.•TuMV HC-Pro p...