Silicate-based bioceramic scaffolds for dual-lineage regeneration of osteochondral defect

• Published in: Biomaterials Vol. 192; pp. 323 - 333
• Main Authors: Bunpetch, Varitsara, Zhang, Xiaoan, Li, Tian, Lin, Junxin, Maswikiti, Ewetse Paul, Wu, Yan, Cai, Dandan, Li, Jun, Zhang, Shufang, Wu, Chengtie, Ouyang, Hongwei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2019
• Subjects: animal models; Animals; bioactive properties; bone formation; bone marrow; Bone Regeneration; calcium phosphates; cartilage; Cells, Cultured; Ceramics - chemistry; chondrocytes; Chondrogenesis; gene ontology; histology; Humans; ions; Mesenchymal Stem Cells - cytology; micro-computed tomography; Osteogenesis; phenotype; quantitative polymerase chain reaction; Rabbits; sequence analysis; Silicates - chemistry; silicon; skeletal development; stem cells; Tissue Engineering; Tissue Scaffolds - chemistry; Western blotting

Osteochondral defects are most commonly characterized by damages to both cartilage and bone tissues as a result of serious traumas or physical diseases; because these two tissues have their own unique biological properties, developing a single monophasic scaffold that can concurrently regenerate the...