Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway - Wang, Meng; Han, Jing; Marcar, Lynnette; Black, Josh; Liu, Qi; Li, Xiangyong; Nagulapalli, Kshithija; Sequist, Lecia V.; Mak, Raymond H.; Benes, Cyril H.; Hong, Theodore S.; Gurtner, Kristin; et al. (Cancer research (Chicago, Ill.), 2017)
Keywords: A549 Cells; Animals; Cancer therapies; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Chromatin; DNA damage; Epidermal growth factor receptors; Female; Genotype & phenotype; Heterografts; Humans; Invasiveness; K-Ras protein; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Lungs; Male; Mice; Mice, Nude; Mitosis; Mutation; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Neoplastic Stem Cells - radiation effects; Osteopontin; Osteopontin - biosynthesis; Osteopontin - genetics; Osteopontin - metabolism; p53 Protein; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Radiation Tolerance - genetics; Receptor, Epidermal Growth Factor - metabolism; Signal Transduction; Treatment resistance