Vitamin D–Related Genetic Variation, Plasma Vitamin D, and Risk of Lethal Prostate Cancer: A Prospective Nested Case–Control Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 104; no. 9; pp. 690 - 699
• Main Authors: Shui, Irene M., Mucci, Lorelei A., Kraft, Peter, Tamimi, Rulla M., Lindstrom, Sara, Penney, Kathryn L., Nimptsch, Katharina, Hollis, Bruce W., DuPre, Natalie, Platz, Elizabeth A., Stampfer, Meir J., Giovannucci, Edward
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 02.05.2012; Oxford Publishing Limited (England)
• Subjects: 25-Hydroxyvitamin D; Aged; Aged, 80 and over; Biological and medical sciences; Case-Control Studies; Genetic diversity; Genetics; genomics; Genotype; Guanylate cyclase; Humans; Kernels; Linkage Disequilibrium; Male; Medical sciences; Mens health; Middle Aged; Nephrology. Urinary tract diseases; Odds Ratio; Oncology; Polymorphism, Single Nucleotide; Prospective Studies; Prostate cancer; Prostatic Neoplasms - blood; Prostatic Neoplasms - genetics; Prostatic Neoplasms - mortality; Retinoid X receptor alpha; Risk Assessment; Risk Factors; Seasons; Signal Transduction; Single-nucleotide polymorphism; Statistical analysis; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - genetics; Vitamin D receptors; Vitamins - blood; Vitamins - genetics; Human; Nephrology; Urinary system disease; Genetic variability; Prostate disease; Genotype; Malignant tumor; Case control study; Lethal character; Epidemiology; Urology; Blood plasma; Prospective; Cancerology; Vitamin D; Risk factor; Genetics; Male genital diseases; Prostate cancer; Public health; Cancer; Polymorphism

The association of vitamin D status with prostate cancer is controversial; no association has been observed for overall incidence, but there is a potential link with lethal disease. We assessed prediagnostic 25-hydroxyvitamin D [25(OH)D] levels in plasma, variation in vitamin D-related genes, and ri...