Evaluation of three hemagglutinin-based vaccines for the experimental control of a panzootic clade 2.3.4.4b A(H5N8) high pathogenicity avian influenza virus in mule ducks

• Published in: Vaccine Vol. 41; no. 1; pp. 145 - 158
• Main Authors: Niqueux, Éric, Flodrops, Marion, Allée, Chantal, Lebras, Marie-Odile, Pierre, Isabelle, Louboutin, Katell, Guillemoto, Carole, Le Prioux, Aurélie, Le Bouquin-Leneveu, Sophie, Keïta, Alassane, Amelot, Michel, Martenot, Claire, Massin, Pascale, Cherbonnel-Pansart, Martine, Briand, François-Xavier, Schmitz, Audrey, Cazaban, Christophe, Dauphin, Gwenaëlle, Delquigny, Thomas, Lemière, Stéphane, Watier, Jean-Marie, Mogler, Mark, Tarpey, Ian, Grasland, Béatrice, Eterradossi, Nicolas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 04.01.2023; Elsevier Limited; Elsevier
• Subjects: Age; Allergy and Immunology; Animal biology; Animals; Antigens; Aquatic birds; Avian flu; Clade 2.3.4.4b A(H5N8); Controlled conditions; Ducks; Enzyme-linked immunosorbent assay; Epizootics; Equidae; Evolution & development; Excretion; Experimental infection; Glycoproteins; Hemagglutination inhibition; Hemagglutinins; High pathogenicity avian influenza; Immunogenicity; Infections; Influenza; Influenza A; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H5N8 Subtype; Influenza in Birds; Influenza Vaccines; Injection; Laboratories; Life Sciences; Mule ducks; Mutation; Pathogenicity; Pathogens; Polymerase chain reaction; Poultry; Poultry Diseases - prevention & control; Serology; Shedding; Vaccination; Vaccines; Vaccines, Synthetic; Veterinary medicine and animal Health; Virulence; Viruses; Waterfowl; Mexico; France; United States > US; China; Indonesia; High pathogenicity avian influenza; Vaccination; Mule ducks; Clade 2.3.4.4b A(H5N8)

•A single injection of homologous hemagglutinin-based RNA or VLP vaccines reduces HP H5N8 shedding in mule ducklings.•A homologous hemagglutinin-based VLP vaccine with high antigen content nearly abrogates respiratory and cloacal shedding.•The three evaluated hemagglutinin-based vaccines allow a sim...