The Ang-(1–7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia

• Published in: PloS one Vol. 19; no. 5; p. e0303150
• Main Authors: Ye, Dan, Liu, Jiamin, Lin, Long, Hou, Pengwei, Feng, Tianshun, Wang, Shousen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.05.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Angiotensin I; Animal experimentation; Animals; Antibodies; Assaying; Brain; Brain Injuries, Traumatic - metabolism; Brain Injuries, Traumatic - pathology; Brain research; Cell Line; Cytokines; Cytokines - metabolism; Damage; Disease Models, Animal; Genetic transformation; Genotype & phenotype; Head injuries; Hypothermia; Hypothermia - metabolism; Hypothermia, Induced; Immunofluorescence; Inflammation; Inflammation - metabolism; Inflammation - pathology; Inflammatory response; Injuries; Interleukins; Laboratory animals; Life sciences; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; Neuroinflammatory Diseases - etiology; Neuroinflammatory Diseases - metabolism; Neuroinflammatory Diseases - pathology; Peptide Fragments; Phenotype; Prognosis; Proteins; Receptors, G-Protein-Coupled - metabolism; Recovery; Reverse transcription; Sea-water; Seawater; Staining; Traumatic brain injury; Western blotting; China; United States > US

The Ang-(1–7)/MasR axis is critically involved in treating several diseases; For example, Ang-(1–7) improves inflammatory response and neurological function after traumatic brain injury and inhibits post-inflammatory hypothermia. However, its function in traumatic brain injury (TBI) combined with se...