Changes in fibrinolysis and severity of organ failure in sepsis: A prospective observational study using point-of-care test—ROTEM

• Published in: Journal of critical care Vol. 30; no. 2; pp. 264 - 270
• Main Authors: Prakash, Shivesh, MD, EDIC, FCICM, Verghese, Santosh, MD, FJFICM, Roxby, David, B App Sc, M App Sc, ARCPA, FFSc, Dixon, Dani, BSc, PhD, Bihari, Shailesh, MD, FCICM, Bersten, Andrew, MD, FJFICM
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015; Elsevier Limited
• Subjects: Adult; Aged; Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Coagulation; Critical Care; Drug dosages; Drug therapy; Female; Fibrin Fibrinogen Degradation Products - analysis; Fibrinolysis; Germany; Hospitals; Humans; Immunoassay; Intensive care; International Normalized Ratio; Laboratories; Male; Middle Aged; Mortality; Peptide Fragments - blood; Plasminogen Activator Inhibitor 1 - blood; Plasminogen activator inhibitor-1; Point-of-Care Systems; Prospective Studies; Proteins; Prothrombin; ROTEM; Sepsis; Sepsis - blood; Thrombelastography; Thromboelastometry; Germany; Thromboelastometry; Sepsis; Plasminogen activator inhibitor-1; Fibrinolysis; Coagulation; ROTEM

Abstract Purpose We hypothesized that the thromboelastometry (ROTEM; Pentapharm GmbH, Munich, Germany) fibrinolysis parameter “maximum lysis” (ML) would have an independent inverse association with the severity of organ failure in sepsis. Methods Selected adult patients with sepsis (n = 77) were rec...