Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection

• Published in: World Journal of Gastroenterology Vol. 20; no. 48; pp. 18249 - 18259
• Main Author: Liu, Xu
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.12.2014
• Subjects: alcohol; Aldehyde Dehydrogenase 1 Family; Animals; class-1; dehydrogenase; Disease Models, Animal; Etha; Ethanol; Ethanol - blood; Ethanol - pharmacokinetics; Fatty Liver, Alcoholic; Fatty Liver, Alcoholic - etiology; Fatty Liver, Alcoholic - genetics; Fatty Liver, Alcoholic - metabolism; Fatty Liver, Alcoholic - physiopathology; Gene Expression Regulation; Hepatectomy; Hepatectomy - adverse effects; Hepatic; Isoenzymes; Isoenzymes - genetics; Isoenzymes - metabolism; Lipid Metabolism; Lipid Metabolism - genetics; Liver; Liver - metabolism; Liver - physiopathology; Liver Regeneration; Male; Metabolic Clearance Rate; Original; Rats, Wistar; Recovery of Function; Retinal Dehydrogenase; Retinal Dehydrogenase - genetics; Retinal Dehydrogenase - metabolism; Risk Factors; RNA, Messenger; RNA, Messenger - metabolism; Hepatic class-1 alcohol dehydrogenase; Liver function; Liver resection; Hepatic steatosis; Ethanol; Ethanol elimination

AIM:To investigate ethanol-induced hepatic steatosis after liver resection and the mechanisms behind it.METHODS:First,the preliminary examination was performed on 6 sham-operated(Sham)and 30 partial hepatectomy(PH)male Wistar rats(8-wk-old)to evaluate the recovery of the liver weight and liver funct...