Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet
The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though...
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Published in | Nutrients Vol. 11; no. 1; p. 207 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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21.01.2019
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Abstract | The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. |
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AbstractList | The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. The approach to studying diet–health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. |
Author | Kales, Stefanos N Sotos-Prieto, Mercedes Black, Alicen Ruiz-Canela, Miguel Vattem, Dhiraj Jin, Qi |
AuthorAffiliation | 1 Division of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA; qj196613@gmail.com (Q.J.); ab914017@ohio.edu (A.B.); vattem@ohio.edu (D.V.) 5 IDISNA, Navarra Health Research Institute, 31008 Pamplona, Spain 6 CIBER Fisiopatología de la Obesidad y Nutrición (CIBER Obn), Instituto de Salud Carlos III, 28029 Madrid, Spain 7 Diabetes Institute, Ohio University, Athens, OH 45701, USA 4 Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain; mcanela@unav.es 2 Department of Environmental Health, Harvard T.H Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; skales@hsph.harvard.edu 3 Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA |
AuthorAffiliation_xml | – name: 1 Division of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA; qj196613@gmail.com (Q.J.); ab914017@ohio.edu (A.B.); vattem@ohio.edu (D.V.) – name: 6 CIBER Fisiopatología de la Obesidad y Nutrición (CIBER Obn), Instituto de Salud Carlos III, 28029 Madrid, Spain – name: 3 Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA – name: 4 Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain; mcanela@unav.es – name: 5 IDISNA, Navarra Health Research Institute, 31008 Pamplona, Spain – name: 7 Diabetes Institute, Ohio University, Athens, OH 45701, USA – name: 2 Department of Environmental Health, Harvard T.H Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; skales@hsph.harvard.edu |
Author_xml | – sequence: 1 givenname: Qi surname: Jin fullname: Jin, Qi email: qj196613@gmail.com organization: Division of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA. qj196613@gmail.com – sequence: 2 givenname: Alicen surname: Black fullname: Black, Alicen email: ab914017@ohio.edu organization: Division of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA. ab914017@ohio.edu – sequence: 3 givenname: Stefanos N surname: Kales fullname: Kales, Stefanos N email: skales@hsph.harvard.edu organization: Department of Environmental Health, 677 Huntington Avenue, Boston, MA 02115, USA. skales@hsph.harvard.edu – sequence: 4 givenname: Dhiraj surname: Vattem fullname: Vattem, Dhiraj email: vattem@ohio.edu, vattem@ohio.edu organization: Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. vattem@ohio.edu – sequence: 5 givenname: Miguel orcidid: 0000-0002-7684-2787 surname: Ruiz-Canela fullname: Ruiz-Canela, Miguel email: mcanela@unav.es, mcanela@unav.es, mcanela@unav.es organization: CIBER Fisiopatología de la Obesidad y Nutrición (CIBER Obn), Instituto de Salud Carlos III, 28029 Madrid, Spain. mcanela@unav.es – sequence: 6 givenname: Mercedes surname: Sotos-Prieto fullname: Sotos-Prieto, Mercedes email: sotospri@ohio.edu, sotospri@ohio.edu, sotospri@ohio.edu organization: Diabetes Institute, Ohio University, Athens, OH 45701, USA. sotospri@ohio.edu |
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Copyright | 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019 |
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Keywords | Mediterranean diet, metabolomics, microbiome |
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SubjectTerms | Cardiovascular Diseases - metabolism Cardiovascular Diseases - microbiology Diet, Mediterranean Feeding Behavior Gastrointestinal Microbiome Healthy Diet Humans Mediterranean diet Metabolome - drug effects Metabolomics microbiome Nutrients - pharmacology Review |
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Title | Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet |
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