Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet

The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though...

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Published inNutrients Vol. 11; no. 1; p. 207
Main Authors Jin, Qi, Black, Alicen, Kales, Stefanos N, Vattem, Dhiraj, Ruiz-Canela, Miguel, Sotos-Prieto, Mercedes
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.01.2019
MDPI
Subjects
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - microbiology
Diet, Mediterranean
Feeding Behavior
Gastrointestinal Microbiome
Healthy Diet
Humans
Mediterranean diet
Metabolome - drug effects
Metabolomics
microbiome
Nutrients - pharmacology
Review
Mediterranean diet, metabolomics, microbiome
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Abstract The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome.
AbstractList The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric mic{Citation}robial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome.
The approach to studying diet–health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome.
The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome.
Author Kales, Stefanos N
Sotos-Prieto, Mercedes
Black, Alicen
Ruiz-Canela, Miguel
Vattem, Dhiraj
Jin, Qi
AuthorAffiliation 1 Division of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA; qj196613@gmail.com (Q.J.); ab914017@ohio.edu (A.B.); vattem@ohio.edu (D.V.)
5 IDISNA, Navarra Health Research Institute, 31008 Pamplona, Spain
6 CIBER Fisiopatología de la Obesidad y Nutrición (CIBER Obn), Instituto de Salud Carlos III, 28029 Madrid, Spain
7 Diabetes Institute, Ohio University, Athens, OH 45701, USA
4 Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain; mcanela@unav.es
2 Department of Environmental Health, Harvard T.H Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; skales@hsph.harvard.edu
3 Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
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– name: 6 CIBER Fisiopatología de la Obesidad y Nutrición (CIBER Obn), Instituto de Salud Carlos III, 28029 Madrid, Spain
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Issue 1
Keywords Mediterranean diet, metabolomics, microbiome
Language English
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Snippet The approach to studying diet⁻health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the...
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SubjectTerms Cardiovascular Diseases - metabolism
Cardiovascular Diseases - microbiology
Diet, Mediterranean
Feeding Behavior
Gastrointestinal Microbiome
Healthy Diet
Humans
Mediterranean diet
Metabolome - drug effects
Metabolomics
microbiome
Nutrients - pharmacology
Review
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Title Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet
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Volume 11
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