Genomic Instability in Cancer: Teetering on the Limit of Tolerance

• Published in: Cancer research (Chicago, Ill.) Vol. 77; no. 9; pp. 2179 - 2185
• Main Authors: Andor, Noemi, Maley, Carlo C., Ji, Hanlee P.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.05.2017
• Subjects: Cancer; Cloning; Copy number; DNA Copy Number Variations - genetics; DNA damage; DNA Damage - genetics; Genetic diversity; Genetic Heterogeneity; Genome, Human; Genomes; Genomic instability; Genomic Instability - genetics; Humans; Immunogenicity; Natural selection; Neoplasms - genetics; Neoplasms - therapy; Plutonium; Prognosis; Solid tumors; Tumors

Cancer genomic instability contributes to the phenomenon of intratumoral genetic heterogeneity, provides the genetic diversity required for natural selection, and enables the extensive phenotypic diversity that is frequently observed among patients. Genomic instability has previously been associated...