In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis

• Published in: Biomaterials Vol. 179; pp. 144 - 155
• Main Authors: Nishiguchi, Akihiro, Matsusaki, Michiya, Kano, Mitsunobu R., Nishihara, Hiroshi, Okano, Daisuke, Asano, Yoshiya, Shimoda, Hiroshi, Kishimoto, Satoko, Iwai, Soichi, Akashi, Mitsuru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2018
• Subjects: angiogenesis; blood; cell culture; drugs; Extracellular matrix; humans; In vitro tumour model; Layer-by-layer assembly; lymph; metalloproteinases; Metastasis; Nanofilm; neoplasm cells; neoplasms; Preclinical assay; prediction; screening; secretion; tissues; Nanofilm; Extracellular matrix; Metastasis; In vitro tumour model; Layer-by-layer assembly; Preclinical assay

Tumour models mimicking in vivo three-dimensional (3D) microenvironments are of increasing interest in drug discovery because of the limitations inherent to current models. For example, preclinical assays that rely on monolayer or spheroid cell cultures cannot easily predict 3D cancer behaviours bec...