Drug-induced lymphocyte stimulation test in the prediction of drug-induced hypersensitivity to antituberculosis drugs

Abstract Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte stimulation test (DLST) in screening ADRs in patients treated with anti-TB drugs, we performed DLST in 272 TB patients (176 cases with ADRs a...

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Published inDiagnostic microbiology and infectious disease Vol. 82; no. 2; pp. 172 - 176
Main Authors Sun, Qin, Sha, Wei, Gui, Xu-Wei, Xiao, Yang-Jiong, Zeng, Wei-Hong, Sun, Wen-Wen, Xiao, He-Ping, Ye, Wei-Yi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2015
Subjects
Adolescent
Adult
Adverse drug reaction
Aged
Aged, 80 and over
Antitubercular Agents - adverse effects
Cytological Techniques - methods
Drug Hypersensitivity
Drug-induced hypersensitivity
Drug-induced lymphocyte stimulation test
Female
Humans
Infectious Disease
Internal Medicine
Lymphocyte Activation - drug effects
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Toxicology - methods
Tuberculosis
Young Adult
Tuberculosis
Adverse drug reaction
Drug-induced hypersensitivity
Drug-induced lymphocyte stimulation test
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Abstract Abstract Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte stimulation test (DLST) in screening ADRs in patients treated with anti-TB drugs, we performed DLST in 272 TB patients (176 cases with ADRs and 96 controls without ADRs) treated with anti-TB drugs isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA). The ADRs were diagnosed by drug provocation test based on clinical and laboratory examinations. The sensitivities of DLST in the diagnosis of INH-, RFP-, EMB-, or PZA-induced ADRs were 57.8%, 37.1%, 42.4%, and 23.1%, respectively, with the corresponding specificities being 93.4%, 94.0%, 97.5%, and 98.8%. DLST has high specificity and limited sensitivity in the diagnosis of anti-TB drug-induced ADRs. In combination with clinical observation and drug use history, DLST could have a predictive validity of ADRs, especially when a positive result is obtained.
AbstractList Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte stimulation test (DLST) in screening ADRs in patients treated with anti-TB drugs, we performed DLST in 272 TB patients (176 cases with ADRs and 96 controls without ADRs) treated with anti-TB drugs isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA). The ADRs were diagnosed by drug provocation test based on clinical and laboratory examinations. The sensitivities of DLST in the diagnosis of INH-, RFP-, EMB-, or PZA-induced ADRs were 57.8%, 37.1%, 42.4%, and 23.1%, respectively, with the corresponding specificities being 93.4%, 94.0%, 97.5%, and 98.8%. DLST has high specificity and limited sensitivity in the diagnosis of anti-TB drug-induced ADRs. In combination with clinical observation and drug use history, DLST could have a predictive validity of ADRs, especially when a positive result is obtained.
Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte stimulation test (DLST) in screening ADRs in patients treated with anti-TB drugs, we performed DLST in 272 TB patients (176 cases with ADRs and 96 controls without ADRs) treated with anti-TB drugs isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA). The ADRs were diagnosed by drug provocation test based on clinical and laboratory examinations. The sensitivities of DLST in the diagnosis of INH-, RFP-, EMB-, or PZA-induced ADRs were 57.8%, 37.1%, 42.4%, and 23.1%, respectively, with the corresponding specificities being 93.4%, 94.0%, 97.5%, and 98.8%. DLST has high specificity and limited sensitivity in the diagnosis of anti-TB drug-induced ADRs. In combination with clinical observation and drug use history, DLST could have a predictive validity of ADRs, especially when a positive result is obtained. •Drug-induced lymphocyte stimulation test (DLST) and drug provocation test (DPT) were compared in detecting adverse drug reactions (ADRs) in TB patients.•Four anti-TB drugs were tested: isoniazid, rifampicin, ethambutol, and pyrazinamide.•DLST has high specificity and limited sensitivity in the diagnosis of anti-TB drug-induced ADRs.
Abstract Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte stimulation test (DLST) in screening ADRs in patients treated with anti-TB drugs, we performed DLST in 272 TB patients (176 cases with ADRs and 96 controls without ADRs) treated with anti-TB drugs isoniazid (INH), rifampicin (RFP), ethambutol (EMB), and pyrazinamide (PZA). The ADRs were diagnosed by drug provocation test based on clinical and laboratory examinations. The sensitivities of DLST in the diagnosis of INH-, RFP-, EMB-, or PZA-induced ADRs were 57.8%, 37.1%, 42.4%, and 23.1%, respectively, with the corresponding specificities being 93.4%, 94.0%, 97.5%, and 98.8%. DLST has high specificity and limited sensitivity in the diagnosis of anti-TB drug-induced ADRs. In combination with clinical observation and drug use history, DLST could have a predictive validity of ADRs, especially when a positive result is obtained.
Author Sha, Wei
Gui, Xu-Wei
Xiao, Yang-Jiong
Sun, Wen-Wen
Xiao, He-Ping
Ye, Wei-Yi
Sun, Qin
Zeng, Wei-Hong
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Issue 2
Keywords Tuberculosis
Adverse drug reaction
Drug-induced hypersensitivity
Drug-induced lymphocyte stimulation test
Language English
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Snippet Abstract Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte...
Antituberculosis (TB) chemotherapeutic drugs may cause a variety of adverse drug reactions (ADRs). To assess the potential of drug-induced lymphocyte...
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StartPage 172
SubjectTerms Adolescent
Adult
Adverse drug reaction
Aged
Aged, 80 and over
Antitubercular Agents - adverse effects
Cytological Techniques - methods
Drug Hypersensitivity
Drug-induced hypersensitivity
Drug-induced lymphocyte stimulation test
Female
Humans
Infectious Disease
Internal Medicine
Lymphocyte Activation - drug effects
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Toxicology - methods
Tuberculosis
Young Adult
Title Drug-induced lymphocyte stimulation test in the prediction of drug-induced hypersensitivity to antituberculosis drugs
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0732889315000747
https://dx.doi.org/10.1016/j.diagmicrobio.2015.03.008
https://www.ncbi.nlm.nih.gov/pubmed/25863530
https://search.proquest.com/docview/1680958139
https://search.proquest.com/docview/1746881500
Volume 82
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