Greater Rupture Risk for Familial as Compared to Sporadic Unruptured Intracranial Aneurysms

• Published in: Stroke (1970) Vol. 40; no. 6; pp. 1952 - 1957
• Main Authors: Broderick, Joseph P., Brown, Robert D., Sauerbeck, Laura, Hornung, Richard, Huston, John, Woo, Daniel, Anderson, Craig, Rouleau, Guy, Kleindorfer, Dawn, Flaherty, Matthew L., Meissner, Irene, Foroud, Tatiana, Charles, E., Moomaw, J., Connolly, E. Sander
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2009
• Subjects: Aneurysm, Ruptured - epidemiology; Aneurysm, Ruptured - genetics; Aneurysm, Ruptured - pathology; Biological and medical sciences; Cerebral Angiography; Diseases of the nervous system; Environment; Female; Follow-Up Studies; Humans; Intracranial Aneurysm - epidemiology; Intracranial Aneurysm - genetics; Intracranial Aneurysm - pathology; Kaplan-Meier Estimate; Life Style; Magnetic Resonance Angiography; Male; Medical sciences; Middle Aged; Neurology; Quality of Life; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk; Risk Factors; Smoking - epidemiology; Survival; Tomography, X-Ray Computed; Vascular diseases and vascular malformations of the nervous system; Stroke; Nervous system diseases; Sporadic; risk of rupture; Rupture; Tobacco smoking; Cardiovascular disease; Cerebral disorder; Vascular disease; familial; intracranial aneurysm; Central nervous system disease; Risk factor; smoking; NMR angiography; magnetic resonance angiography; Cerebrovascular disease

Background and Purpose— The risk of intracranial aneurysm (IA) rupture in asymptomatic members of families who have multiple affected individuals is not known. Methods— First-degree unaffected relatives of those with a familial history of IA who had a history of smoking or hypertension but no known...