The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects - Stangier, Joachim; Rathgen, Karin; Stähle, Hildegard; Gansser, Dietmar; Roth, Willy (British journal of clinical pharmacology, 2007)
Keywords: activated partial thromboplastin time; Administration, Oral; Adolescent; Adult; Anticoagulants - blood; Anticoagulants - pharmacokinetics; Anticoagulants - pharmacology; Area Under Curve; Benzimidazoles - blood; Benzimidazoles - pharmacokinetics; Benzimidazoles - pharmacology; Blood Coagulation Tests; Dabigatran; dabigatran etexilate; direct thrombin inhibitor; Dose-Response Relationship, Drug; Double-Blind Method; ecarin clotting time; Humans; Male; Middle Aged; pharmacodynamics; Pharmacokinetics & Pharmacodynamics; Pyridines - blood; Pyridines - pharmacokinetics; Pyridines - pharmacology