Role of P2Y1 purinoceptor in ADP-induced platelet activation

• Published in: FEBS letters Vol. 422; no. 3; pp. 291 - 295
• Main Authors: Savi, P, Beauverger, P, Labouret, C, Delfaud, M, Salel, V, Kaghad, M, Herbert, J.M
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 06.02.1998
• Subjects: Adenosine diphosphate; Adenosine Diphosphate - physiology; Animals; Calcium - metabolism; Clopidogrel; Humans; In Vitro Techniques; P2Y1 purinoceptor; Platelet Activation - drug effects; Platelet Activation - physiology; Platelet aggregation; Platelet Aggregation Inhibitors - pharmacology; Polymerase Chain Reaction; Rabbits; Receptors, Purinergic P2 - drug effects; Receptors, Purinergic P2 - physiology; Receptors, Purinergic P2Y1; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology; Adenosine diphosphate; Platelet aggregation; P2Y1 purinoceptor

ADP acts as an agonist of platelet aggregation via specific receptors which are still to be characterised. Amplification by PCR of a human platelet cDNA library confirmed the presence of mRNA of the P2Y1 receptor in platelets. In order to determine if these P2Y1 receptors were involved in ADP-induce...