Prospective Echocardiographic and Tissue Doppler Imaging Screening of a Population of Maine Coon Cats Tested for the A31P Mutation in the Myosin-Binding Protein C Gene: A Specific Analysis of the Heterozygous Status

• Published in: Journal of veterinary internal medicine Vol. 23; no. 1; pp. 91 - 99
• Main Authors: Carlos Sampedrano, C, Chetboul, V, Mary, J, Tissier, R, Abitbol, M, Serres, F, Gouni, V, Thomas, A, Pouchelon, J.L
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 2009; Wiley
• Subjects: Animal biology; Animals; Cardiomyopathy; Cardiomyopathy, Hypertrophic - genetics; Cardiomyopathy, Hypertrophic - veterinary; Carrier Proteins - genetics; Cat Diseases - genetics; Cats; Echocardiography; Echocardiography - veterinary; Feline; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Homozygote; Life Sciences; Loss of Heterozygosity; Male; Mutation; myosin; phenotype; Veterinary medicine and animal Health; feline; cardiomyopathy; echocardiography; genotype

Background: A mutation in the sarcomeric gene coding for the myosin‐binding protein C gene has been identified in a colony of Maine Coon cats with hypertrophic cardiomyopathy (MyBPC3‐A31P mutation). However, the close correlation between genotype and phenotype (left ventricular hypertrophy [LVH] and...