Mechanisms of Venous Thrombosis and Resolution
Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only...
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| Published in | Arteriosclerosis, thrombosis, and vascular biology Vol. 28; no. 3; pp. 387 - 391 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Heart Association, Inc
01.03.2008
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies. |
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| AbstractList | Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies. |
| Author | Wakefield, Thomas W Henke, Peter K Myers, Daniel D |
| AuthorAffiliation | From the Section of Vascular Surgery, Department of Surgery (T.W.W., D.D.M., P.K.H.) and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor |
| AuthorAffiliation_xml | – name: From the Section of Vascular Surgery, Department of Surgery (T.W.W., D.D.M., P.K.H.) and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor |
| Author_xml | – sequence: 1 givenname: Thomas surname: Wakefield middlename: W fullname: Wakefield, Thomas W organization: From the Section of Vascular Surgery, Department of Surgery (T.W.W., D.D.M., P.K.H.) and Unit for Laboratory Animal Medicine (D.D.M.), University of Michigan, Ann Arbor – sequence: 2 givenname: Daniel surname: Myers middlename: D fullname: Myers, Daniel D – sequence: 3 givenname: Peter surname: Henke middlename: K fullname: Henke, Peter K |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18296594$$D View this record in MEDLINE/PubMed |
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| PublicationDate_xml | – month: 03 year: 2008 text: 2008-March |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
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| PublicationTitle | Arteriosclerosis, thrombosis, and vascular biology |
| PublicationTitleAlternate | Arterioscler Thromb Vasc Biol |
| PublicationYear | 2008 |
| Publisher | American Heart Association, Inc |
| Publisher_xml | – name: American Heart Association, Inc |
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| SubjectTerms | Animals Cell Adhesion Molecules - drug effects Cell Adhesion Molecules - metabolism Clot Retraction - drug effects Clot Retraction - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Humans Mice P-Selectin - metabolism Platelet Activation - drug effects Platelet Activation - physiology Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Rats Sensitivity and Specificity Treatment Outcome Venous Thrombosis - physiopathology |
| Title | Mechanisms of Venous Thrombosis and Resolution |
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