Mechanisms of Venous Thrombosis and Resolution

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 28; no. 3; pp. 387 - 391
• Main Authors: Wakefield, Thomas W, Myers, Daniel D, Henke, Peter K
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.03.2008
• Subjects: Animals; Cell Adhesion Molecules - drug effects; Cell Adhesion Molecules - metabolism; Clot Retraction - drug effects; Clot Retraction - physiology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Humans; Mice; P-Selectin - metabolism; Platelet Activation - drug effects; Platelet Activation - physiology; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Rats; Sensitivity and Specificity; Treatment Outcome; Venous Thrombosis - physiopathology
• ISSN: 1079-5642; 1524-4636
• DOI: 10.1161/ATVBAHA.108.162289

Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies.