Stearidonic Acid-Enriched Soybean Oil Increased the Omega-3 Index, an Emerging Cardiovascular Risk Marker

A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modi...

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Bibliographic Details
Published inLipids Vol. 43; no. 9; pp. 805 - 811
Main Authors Harris, William S., Lemke, Shawna L., Hansen, Susan N., Goldstein, Daniel A., DiRienzo, Maureen A., Su, Hong, Nemeth, Margaret A., Taylor, Mary L., Ahmed, Gulam, George, Cherian
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.09.2008
Springer-Verlag
Springer‐Verlag
Springer Nature B.V
Subjects
Adult
Aged
biomarkers
Biomedical and Life Sciences
blood
Blood pressure
Cardiovascular disease
cardiovascular diseases
Cardiovascular Diseases - etiology
chemistry
dietary fat
docosahexaenoic acid
eicosapentaenoic acid
emerging diseases
Erythrocytes
Erythrocytes - chemistry
Esters
etiology
fatty acid composition
Fatty Acids, Omega-3
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-3 - pharmacology
Female
Genetically modified organisms
Glycine max
Health risks
Heart rate
human health
human nutrition
Humans
Laboratory tests
Life Sciences
Lipidology
Lipids
Male
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Middle Aged
Neurochemistry
Nutrition
Omega‐3 fatty acids
Original Article
pharmacology
Risk Factors
Soybean oil
Soybean Oil - pharmacology
Soybeans
Stearidonic acid
transgenic plants
Cardiovascular disease
Soybean oil
Stearidonic acid
Omega-3 fatty acids
Risk factors
Genetically modified organisms
Online AccessGet full text
ISSN0024-4201
1558-9307
DOI10.1007/s11745-008-3215-0

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Abstract A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA + DHA levels (the omega-3 index). Overweight healthy volunteers (n = 45) were randomized to SDA-SBO (24 ml/day providing ~3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (~1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p < 0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
AbstractList A plant source of omega‐3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta‐6 desaturase product of alpha‐linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA‐SBO on erythrocyte EPA + DHA levels (the omega‐3 index). Overweight healthy volunteers (n = 45) were randomized to SDA‐SBO (24 ml/day providing ~3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (~1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega‐3 index. A per‐protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega‐3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p < 0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA‐enriched SBO significantly raised the omega‐3 index. Since EPA supplementation has been shown to raise the omega‐3 index and to lower risk for cardiac events, SDA‐SBO may be a viable plant‐based alternative for providing meaningful intakes of cardioprotective omega‐3 FAs.
A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA + DHA levels (the omega-3 index). Overweight healthy volunteers ( n  = 45) were randomized to SDA-SBO (24 ml/day providing ~3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (~1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group ( p  < 0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
A plant source of omega‐3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta‐6 desaturase product of alpha‐linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA‐SBO on erythrocyte EPA + DHA levels (the omega‐3 index). Overweight healthy volunteers ( n = 45) were randomized to SDA‐SBO (24 ml/day providing ~3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (~1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega‐3 index. A per‐protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega‐3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group ( p < 0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA‐enriched SBO significantly raised the omega‐3 index. Since EPA supplementation has been shown to raise the omega‐3 index and to lower risk for cardiac events, SDA‐SBO may be a viable plant‐based alternative for providing meaningful intakes of cardioprotective omega‐3 FAs.
A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
Author Harris, William S.
Taylor, Mary L.
Su, Hong
Lemke, Shawna L.
DiRienzo, Maureen A.
Hansen, Susan N.
Goldstein, Daniel A.
Ahmed, Gulam
George, Cherian
Nemeth, Margaret A.
Author_xml – sequence: 1
  givenname: William S.
  surname: Harris
  fullname: Harris, William S.
  email: harrisw@sanfordhealth.org
  organization: Sanford Research/USD
– sequence: 2
  givenname: Shawna L.
  surname: Lemke
  fullname: Lemke, Shawna L.
  organization: Product Safety Center, Monsanto Company
– sequence: 3
  givenname: Susan N.
  surname: Hansen
  fullname: Hansen, Susan N.
  organization: Sanford Research/USD
– sequence: 4
  givenname: Daniel A.
  surname: Goldstein
  fullname: Goldstein, Daniel A.
  organization: Product Safety Center, Monsanto Company
– sequence: 5
  givenname: Maureen A.
  surname: DiRienzo
  fullname: DiRienzo, Maureen A.
  organization: Product Safety Center, Monsanto Company
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  givenname: Hong
  surname: Su
  fullname: Su, Hong
  organization: Product Safety Center, Monsanto Company
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  fullname: Nemeth, Margaret A.
  organization: Product Safety Center, Monsanto Company
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  givenname: Mary L.
  surname: Taylor
  fullname: Taylor, Mary L.
  organization: Product Safety Center, Monsanto Company
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  givenname: Gulam
  surname: Ahmed
  fullname: Ahmed, Gulam
  organization: Product Safety Center, Monsanto Company
– sequence: 10
  givenname: Cherian
  surname: George
  fullname: George, Cherian
  organization: Product Safety Center, Monsanto Company
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18683001$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s11745-006-1392-2
10.1097/00075197-200203000-00002
10.1161/CIRCULATIONAHA.105.545640
10.1139/H07-034
10.1016/j.ypmed.2004.02.030
10.1161/CIRCULATIONAHA.104.489534
10.1161/CIRCULATIONAHA.105.581355
10.1126/science.1132294
10.1079/BJN20041131
10.1161/01.CIR.0000038493.65177.94
10.1016/j.phrs.2007.01.013
10.1161/01.CIR.0000142292.10048.B2
10.1016/S0140-6736(07)60527-3
10.1146/annurev.nutr.25.050304.092605
10.1001/jama.274.17.1363
10.1161/CIRCULATIONAHA.105.572008
10.1016/j.plefa.2003.11.008
10.1056/NEJMoa012918
10.1093/ajcn/83.6.1526S
10.1016/0005-2760(92)90166-S
10.1093/jn/133.12.4271
10.1136/bmj.313.7049.84
10.1093/ajcn/71.1.179S
10.1001/jama.1995.03530170043030
10.1093/jn/134.6.1406
10.1093/ajcp/85.1.50
10.1093/ajcn/84.1.5
10.1093/ajcn/85.5.1222
10.1093/ajcn/77.5.1140
10.1016/S0022-2275(20)31576-5
10.1093/ajcn/84.1.44
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Keywords Cardiovascular disease
Soybean oil
Stearidonic acid
Omega-3 fatty acids
Risk factors
Genetically modified organisms
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References Harris (CR26) 2005; 111
Kris-Etherton, Taylor, Yu-Poth (CR3) 2000; 71
Whelan, Rust (CR27) 2006; 26
Gebauer, Psota, Harris, Kris-Etherton (CR9) 2006; 83
Iso, Kobayashi, Ishihara (CR31) 2006; 113
Ursin (CR14) 2003; 133
CR18
Ascherio, Rimm, Giovannucci, Spiegelman, Stampfer, Willett (CR25) 1996; 313
Wang, Harris, Chung (CR1) 2006; 84
Yamazaki, Fujikawa, Hamazaki, Yano, Shono (CR13) 1992; 1123
Kris-Etherton, Harris, Appel (CR8) 2002; 106
Siscovick, Raghunathan, King (CR19) 1995; 274
Harris, von Schacky (CR21) 2008; 2
Miles, Banerjee, Dooper, M’Rabet, Graus, Calder (CR28) 2004; 91
Djousse, Arnett, Carr (CR24) 2005; 111
Pawlosky, Hibbeln, Novotny, Salem (CR17) 2001; 42
Plourde, Cunnane (CR12) 2007; 32
Harris, Sands, Windsor (CR5) 2004; 110
Harris, von Schacky (CR4) 2004; 39
Albert, Oh, Whang (CR23) 2005; 112
Brenna (CR11) 2002; 5
Surette, Edens, Chilton, Tramposch (CR30) 2004; 134
Yokoyama, Origasa, Matsuzaki (CR2) 2007; 369
Harris (CR7) 2007; 55
Metcalf, James, Gibson (CR6) 2007; 85
Riess, Braun, Brehm, Hiller (CR15) 1986; 85
Worm, Barbier, Beaumont (CR10) 2006; 314
Albert, Campos, Stampfer (CR20) 2002; 346
Miles, Banerjee, Calder (CR29) 2004; 70
Sands, Reid, Windsor, Harris (CR22) 2005; 40
James, Ursin, Cleland (CR16) 2003; 77
2007; 369
2005; 111
1992; 1123
2005; 112
2002; 5
2005; 40
2000; 71
2006
2006; 314
2007; 32
1995; 274
2008; 2
2004; 91
2007; 55
2003; 133
2003; 77
2001; 42
2006; 113
2004; 134
2004; 110
2006; 83
2004; 70
2006; 84
1986; 85
2004; 39
2006; 26
2002; 106
2002; 346
2007; 85
1996; 313
e_1_2_6_32_1
e_1_2_6_10_1
e_1_2_6_31_1
e_1_2_6_30_1
Harris WS (e_1_2_6_22_1) 2008; 2
e_1_2_6_19_1
e_1_2_6_13_1
e_1_2_6_14_1
e_1_2_6_11_1
e_1_2_6_12_1
e_1_2_6_17_1
e_1_2_6_18_1
e_1_2_6_15_1
e_1_2_6_16_1
e_1_2_6_21_1
e_1_2_6_20_1
e_1_2_6_9_1
e_1_2_6_8_1
e_1_2_6_5_1
e_1_2_6_4_1
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e_1_2_6_26_1
12438303 - Circulation. 2002 Nov 19;106(21):2747-57
15182393 - Br J Nutr. 2004 Jun;91(6):893-903
17082450 - Science. 2006 Nov 3;314(5800):787-90
15173404 - J Nutr. 2004 Jun;134(6):1406-11
11948270 - N Engl J Med. 2002 Apr 11;346(15):1113-8
15208005 - Prev Med. 2004 Jul;39(1):212-20
15120716 - Prostaglandins Leukot Essent Fatty Acids. 2004 Jun;70(6):529-38
12716664 - Am J Clin Nutr. 2003 May;77(5):1140-5
17324586 - Pharmacol Res. 2007 Mar;55(3):217-23
15927976 - Circulation. 2005 Jun 7;111(22):2921-6
10617969 - Am J Clin Nutr. 2000 Jan;71(1 Suppl):179S-88S
15939831 - Circulation. 2005 Jun 7;111(22):2872-4
16028715 - Lipids. 2005 Apr;40(4):343-7
16825680 - Am J Clin Nutr. 2006 Jul;84(1):44-53
16825676 - Am J Clin Nutr. 2006 Jul;84(1):5-17
1346092 - Biochim Biophys Acta. 1992 Jan 3;1123(1):18-26
14652387 - J Nutr. 2003 Dec;133(12 ):4271-4
8688759 - BMJ. 1996 Jul 13;313(7049):84-90
16401768 - Circulation. 2006 Jan 17;113(2):195-202
17398308 - Lancet. 2007 Mar 31;369(9567):1090-8
16848701 - Annu Rev Nutr. 2006;26:75-103
16301356 - Circulation. 2005 Nov 22;112(21):3232-8
7563561 - JAMA. 1995 Nov 1;274(17):1363-7
17490956 - Am J Clin Nutr. 2007 May;85(5):1222-8
15353491 - Circulation. 2004 Sep 21;110(12):1645-9
16841863 - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S
11844977 - Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):127-32
17622276 - Appl Physiol Nutr Metab. 2007 Aug;32(4):619-34
11483627 - J Lipid Res. 2001 Aug;42(8):1257-65
3079628 - Am J Clin Pathol. 1986 Jan;85(1):50-6
References_xml – volume: 71
  start-page: 179S
  year: 2000
  end-page: 188S
  ident: CR3
  article-title: Polyunsaturated fatty acids in the food chain in the United States
  publication-title: Am J Clin Nutr
– volume: 40
  start-page: 343
  year: 2005
  end-page: 347
  ident: CR22
  article-title: The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes
  publication-title: Lipids
  doi: 10.1007/s11745-006-1392-2
– ident: CR18
– volume: 134
  start-page: 1406
  year: 2004
  end-page: 1411
  ident: CR30
  article-title: Dietary echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans
  publication-title: J Nutr
– volume: 85
  start-page: 1222
  year: 2007
  end-page: 1228
  ident: CR6
  article-title: Effects of fish-oil supplementation on myocardial fatty acids in humans
  publication-title: Am J Clin Nutr
– volume: 5
  start-page: 127
  year: 2002
  end-page: 132
  ident: CR11
  article-title: Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man
  publication-title: Curr Opin Clin Nutr Metab Care
  doi: 10.1097/00075197-200203000-00002
– volume: 111
  start-page: 2872
  year: 2005
  end-page: 2874
  ident: CR26
  article-title: Alpha-linolenic acid—a gift from the land?
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.545640
– volume: 32
  start-page: 619
  year: 2007
  end-page: 634
  ident: CR12
  article-title: Extremely limited synthesis of long chain polyunsaturates in adults: implications for their essentiality and use as supplements
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/H07-034
– volume: 39
  start-page: 212
  year: 2004
  end-page: 220
  ident: CR4
  article-title: The omega-3 index: a new risk factor for death from coronary heart disease?
  publication-title: Prev Med
  doi: 10.1016/j.ypmed.2004.02.030
– volume: 111
  start-page: 2921
  year: 2005
  end-page: 2926
  ident: CR24
  article-title: Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI family heart study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.104.489534
– volume: 113
  start-page: 195
  year: 2006
  end-page: 202
  ident: CR31
  article-title: Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese: the Japan public health center-based (JPHC) study cohort I
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.581355
– volume: 314
  start-page: 787
  year: 2006
  end-page: 790
  ident: CR10
  article-title: Impacts of biodiversity loss on ocean ecosystem services
  publication-title: Science
  doi: 10.1126/science.1132294
– volume: 91
  start-page: 893
  year: 2004
  end-page: 903
  ident: CR28
  article-title: The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
  publication-title: Br J Nutr
  doi: 10.1079/BJN20041131
– volume: 77
  start-page: 1140
  year: 2003
  end-page: 1145
  ident: CR16
  article-title: Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
  publication-title: Am J Clin Nutr
– volume: 106
  start-page: 2747
  year: 2002
  end-page: 2757
  ident: CR8
  article-title: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000038493.65177.94
– volume: 55
  start-page: 217
  year: 2007
  end-page: 223
  ident: CR7
  article-title: Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2007.01.013
– volume: 85
  start-page: 50
  year: 1986
  end-page: 56
  ident: CR15
  article-title: Critical evaluation of platelet aggregation in whole human blood
  publication-title: Am J Clin Pathol
– volume: 1123
  start-page: 18
  year: 1992
  end-page: 26
  ident: CR13
  article-title: Comparison of the conversion rates of alpha-linolenic acid (18:3(n-3)) and stearidonic acid (18:4(n-3)) to longer polyunsaturated fatty acids in rats
  publication-title: Biochim Biophys Acta
– volume: 110
  start-page: 1645
  year: 2004
  end-page: 1649
  ident: CR5
  article-title: Omega-3 fatty acids in cardiac biopsies from heart transplant patients: correlation with erythrocytes and response to supplementation
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000142292.10048.B2
– volume: 42
  start-page: 1257
  year: 2001
  end-page: 1265
  ident: CR17
  article-title: Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans
  publication-title: J Lipid Res
– volume: 133
  start-page: 4271
  year: 2003
  end-page: 4274
  ident: CR14
  article-title: Modification of plant lipids for human health: development of functional land-based omega-3 fatty acids
  publication-title: J Nutr
– volume: 84
  start-page: 5
  year: 2006
  end-page: 17
  ident: CR1
  article-title: n-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
  publication-title: Am J Clin Nutr
– volume: 369
  start-page: 1090
  year: 2007
  end-page: 1098
  ident: CR2
  article-title: Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)60527-3
– volume: 26
  start-page: 75
  year: 2006
  end-page: 103
  ident: CR27
  article-title: Innovative dietary sources of n-3 fatty acids
  publication-title: Annu Rev Nutr
  doi: 10.1146/annurev.nutr.25.050304.092605
– volume: 83
  start-page: 1526S
  year: 2006
  end-page: 1535S
  ident: CR9
  article-title: n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
  publication-title: Am J Clin Nutr
– volume: 274
  start-page: 1363
  year: 1995
  end-page: 1367
  ident: CR19
  article-title: Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
  publication-title: J Am Med Assoc
  doi: 10.1001/jama.274.17.1363
– volume: 112
  start-page: 3232
  year: 2005
  end-page: 3238
  ident: CR23
  article-title: Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.572008
– volume: 70
  start-page: 529
  year: 2004
  end-page: 538
  ident: CR29
  article-title: The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers
  publication-title: Prostaglandins Leukot Essent Fatty Acids
  doi: 10.1016/j.plefa.2003.11.008
– volume: 346
  start-page: 1113
  year: 2002
  end-page: 1118
  ident: CR20
  article-title: Blood levels of long-chain n-3 fatty acids and the risk of sudden death
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa012918
– volume: 2
  start-page: 161
  year: 2008
  end-page: 166
  ident: CR21
  article-title: Omega-3 fatty acids, acute coronary syndrome and sudden death
  publication-title: Curr Hypertens Rep
– volume: 313
  start-page: 84
  year: 1996
  end-page: 90
  ident: CR25
  article-title: Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
  publication-title: BMJ
– volume: 42
  start-page: 1257
  year: 2001
  end-page: 1265
  article-title: Physiological compartmental analysis of alpha‐linolenic acid metabolism in adult humans
  publication-title: J Lipid Res
– volume: 134
  start-page: 1406
  year: 2004
  end-page: 1411
  article-title: Dietary echium oil increases plasma and neutrophil long‐chain (n‐3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans
  publication-title: J Nutr
– volume: 314
  start-page: 787
  year: 2006
  end-page: 790
  article-title: Impacts of biodiversity loss on ocean ecosystem services
  publication-title: Science
– volume: 55
  start-page: 217
  year: 2007
  end-page: 223
  article-title: Omega‐3 fatty acids and cardiovascular disease: a case for omega‐3 index as a new risk factor
  publication-title: Pharmacol Res
– volume: 313
  start-page: 84
  year: 1996
  end-page: 90
  article-title: Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
  publication-title: BMJ
– volume: 84
  start-page: 5
  year: 2006
  end-page: 17
  article-title: n‐3 fatty acids from fish or fish‐oil supplements, but not alpha‐linolenic acid, benefit cardiovascular disease outcomes in primary‐ and secondary‐prevention studies: a systematic review
  publication-title: Am J Clin Nutr
– volume: 5
  start-page: 127
  year: 2002
  end-page: 132
  article-title: Efficiency of conversion of alpha‐linolenic acid to long chain n‐3 fatty acids in man
  publication-title: Curr Opin Clin Nutr Metab Care
– volume: 40
  start-page: 343
  year: 2005
  end-page: 347
  article-title: The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes
  publication-title: Lipids
– volume: 111
  start-page: 2872
  year: 2005
  end-page: 2874
  article-title: Alpha‐linolenic acid—a gift from the land?
  publication-title: Circulation
– volume: 110
  start-page: 1645
  year: 2004
  end-page: 1649
  article-title: Omega‐3 fatty acids in cardiac biopsies from heart transplant patients: correlation with erythrocytes and response to supplementation
  publication-title: Circulation
– volume: 369
  start-page: 1090
  year: 2007
  end-page: 1098
  article-title: Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open‐label, blinded endpoint analysis
  publication-title: Lancet
– volume: 111
  start-page: 2921
  year: 2005
  end-page: 2926
  article-title: Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI family heart study
  publication-title: Circulation
– volume: 1123
  start-page: 18
  year: 1992
  end-page: 26
  article-title: Comparison of the conversion rates of alpha‐linolenic acid (18:3(n‐3)) and stearidonic acid (18:4(n‐3)) to longer polyunsaturated fatty acids in rats
  publication-title: Biochim Biophys Acta
– volume: 2
  start-page: 161
  year: 2008
  end-page: 166
  article-title: Omega‐3 fatty acids, acute coronary syndrome and sudden death
  publication-title: Curr Hypertens Rep
– volume: 113
  start-page: 195
  year: 2006
  end-page: 202
  article-title: Intake of fish and n‐3 fatty acids and risk of coronary heart disease among Japanese: the Japan public health center‐based (JPHC) study cohort I
  publication-title: Circulation
– volume: 71
  start-page: 179S
  year: 2000
  end-page: 188S
  article-title: Polyunsaturated fatty acids in the food chain in the United States
  publication-title: Am J Clin Nutr
– volume: 112
  start-page: 3232
  year: 2005
  end-page: 3238
  article-title: Dietary alpha‐linolenic acid intake and risk of sudden cardiac death and coronary heart disease
  publication-title: Circulation
– volume: 32
  start-page: 619
  year: 2007
  end-page: 634
  article-title: Extremely limited synthesis of long chain polyunsaturates in adults: implications for their essentiality and use as supplements
  publication-title: Appl Physiol Nutr Metab
– volume: 77
  start-page: 1140
  year: 2003
  end-page: 1145
  article-title: Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n‐3 fatty acids
  publication-title: Am J Clin Nutr
– volume: 346
  start-page: 1113
  year: 2002
  end-page: 1118
  article-title: Blood levels of long‐chain n‐3 fatty acids and the risk of sudden death
  publication-title: N Engl J Med
– volume: 91
  start-page: 893
  year: 2004
  end-page: 903
  article-title: The influence of different combinations of gamma‐linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
  publication-title: Br J Nutr
– volume: 83
  start-page: 1526S
  year: 2006
  end-page: 1535S
  article-title: n‐3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
  publication-title: Am J Clin Nutr
– volume: 26
  start-page: 75
  year: 2006
  end-page: 103
  article-title: Innovative dietary sources of n‐3 fatty acids
  publication-title: Annu Rev Nutr
– volume: 70
  start-page: 529
  year: 2004
  end-page: 538
  article-title: The influence of different combinations of gamma‐linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers
  publication-title: Prostaglandins Leukot Essent Fatty Acids
– volume: 85
  start-page: 1222
  year: 2007
  end-page: 1228
  article-title: Effects of fish‐oil supplementation on myocardial fatty acids in humans
  publication-title: Am J Clin Nutr
– volume: 39
  start-page: 212
  year: 2004
  end-page: 220
  article-title: The omega‐3 index: a new risk factor for death from coronary heart disease?
  publication-title: Prev Med
– volume: 274
  start-page: 1363
  year: 1995
  end-page: 1367
  article-title: Dietary intake and cell membrane levels of long‐chain n‐3 polyunsaturated fatty acids and the risk of primary cardiac arrest
  publication-title: J Am Med Assoc
– year: 2006
  article-title: Conversion of alpha‐linolenic acid in humans is influenced by the absolute amounts of alpha‐linolenic acid and linoleic acid in the diet, and not by their ratio
– volume: 106
  start-page: 2747
  year: 2002
  end-page: 2757
  article-title: Fish consumption, fish oil, omega‐3 fatty acids, and cardiovascular disease
  publication-title: Circulation
– volume: 133
  start-page: 4271
  year: 2003
  end-page: 4274
  article-title: Modification of plant lipids for human health: development of functional land‐based omega‐3 fatty acids
  publication-title: J Nutr
– volume: 85
  start-page: 50
  year: 1986
  end-page: 56
  article-title: Critical evaluation of platelet aggregation in whole human blood
  publication-title: Am J Clin Pathol
– ident: e_1_2_6_10_1
  doi: 10.1093/ajcn/83.6.1526S
– ident: e_1_2_6_14_1
  doi: 10.1016/0005-2760(92)90166-S
– ident: e_1_2_6_29_1
  doi: 10.1079/BJN20041131
– ident: e_1_2_6_25_1
  doi: 10.1161/CIRCULATIONAHA.104.489534
– ident: e_1_2_6_27_1
  doi: 10.1161/CIRCULATIONAHA.105.545640
– ident: e_1_2_6_23_1
  doi: 10.1007/s11745-006-1392-2
– ident: e_1_2_6_15_1
  doi: 10.1093/jn/133.12.4271
– ident: e_1_2_6_32_1
  doi: 10.1161/CIRCULATIONAHA.105.581355
– ident: e_1_2_6_26_1
  doi: 10.1136/bmj.313.7049.84
– ident: e_1_2_6_28_1
  doi: 10.1146/annurev.nutr.25.050304.092605
– ident: e_1_2_6_4_1
  doi: 10.1093/ajcn/71.1.179S
– ident: e_1_2_6_11_1
  doi: 10.1126/science.1132294
– ident: e_1_2_6_20_1
  doi: 10.1001/jama.1995.03530170043030
– ident: e_1_2_6_3_1
  doi: 10.1016/S0140-6736(07)60527-3
– ident: e_1_2_6_30_1
  doi: 10.1016/j.plefa.2003.11.008
– ident: e_1_2_6_21_1
  doi: 10.1056/NEJMoa012918
– ident: e_1_2_6_31_1
  doi: 10.1093/jn/134.6.1406
– ident: e_1_2_6_12_1
  doi: 10.1097/00075197-200203000-00002
– volume: 2
  start-page: 161
  year: 2008
  ident: e_1_2_6_22_1
  article-title: Omega‐3 fatty acids, acute coronary syndrome and sudden death
  publication-title: Curr Hypertens Rep
– ident: e_1_2_6_16_1
  doi: 10.1093/ajcp/85.1.50
– ident: e_1_2_6_9_1
  doi: 10.1161/01.CIR.0000038493.65177.94
– ident: e_1_2_6_13_1
  doi: 10.1139/H07-034
– ident: e_1_2_6_2_1
  doi: 10.1093/ajcn/84.1.5
– ident: e_1_2_6_5_1
  doi: 10.1016/j.ypmed.2004.02.030
– ident: e_1_2_6_7_1
  doi: 10.1093/ajcn/85.5.1222
– ident: e_1_2_6_17_1
  doi: 10.1093/ajcn/77.5.1140
– ident: e_1_2_6_6_1
  doi: 10.1161/01.CIR.0000142292.10048.B2
– ident: e_1_2_6_8_1
  doi: 10.1016/j.phrs.2007.01.013
– ident: e_1_2_6_24_1
  doi: 10.1161/CIRCULATIONAHA.105.572008
– ident: e_1_2_6_18_1
  doi: 10.1016/S0022-2275(20)31576-5
– ident: e_1_2_6_19_1
  doi: 10.1093/ajcn/84.1.44
– reference: 15208005 - Prev Med. 2004 Jul;39(1):212-20
– reference: 17622276 - Appl Physiol Nutr Metab. 2007 Aug;32(4):619-34
– reference: 1346092 - Biochim Biophys Acta. 1992 Jan 3;1123(1):18-26
– reference: 12716664 - Am J Clin Nutr. 2003 May;77(5):1140-5
– reference: 11948270 - N Engl J Med. 2002 Apr 11;346(15):1113-8
– reference: 15939831 - Circulation. 2005 Jun 7;111(22):2872-4
– reference: 14652387 - J Nutr. 2003 Dec;133(12 ):4271-4
– reference: 15120716 - Prostaglandins Leukot Essent Fatty Acids. 2004 Jun;70(6):529-38
– reference: 15353491 - Circulation. 2004 Sep 21;110(12):1645-9
– reference: 11483627 - J Lipid Res. 2001 Aug;42(8):1257-65
– reference: 7563561 - JAMA. 1995 Nov 1;274(17):1363-7
– reference: 10617969 - Am J Clin Nutr. 2000 Jan;71(1 Suppl):179S-88S
– reference: 8688759 - BMJ. 1996 Jul 13;313(7049):84-90
– reference: 12438303 - Circulation. 2002 Nov 19;106(21):2747-57
– reference: 16301356 - Circulation. 2005 Nov 22;112(21):3232-8
– reference: 16841863 - Am J Clin Nutr. 2006 Jun;83(6 Suppl):1526S-1535S
– reference: 15927976 - Circulation. 2005 Jun 7;111(22):2921-6
– reference: 17490956 - Am J Clin Nutr. 2007 May;85(5):1222-8
– reference: 16825680 - Am J Clin Nutr. 2006 Jul;84(1):44-53
– reference: 11844977 - Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):127-32
– reference: 15182393 - Br J Nutr. 2004 Jun;91(6):893-903
– reference: 3079628 - Am J Clin Pathol. 1986 Jan;85(1):50-6
– reference: 16848701 - Annu Rev Nutr. 2006;26:75-103
– reference: 17324586 - Pharmacol Res. 2007 Mar;55(3):217-23
– reference: 16825676 - Am J Clin Nutr. 2006 Jul;84(1):5-17
– reference: 17082450 - Science. 2006 Nov 3;314(5800):787-90
– reference: 16028715 - Lipids. 2005 Apr;40(4):343-7
– reference: 16401768 - Circulation. 2006 Jan 17;113(2):195-202
– reference: 15173404 - J Nutr. 2004 Jun;134(6):1406-11
– reference: 17398308 - Lancet. 2007 Mar 31;369(9567):1090-8
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Snippet A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO)...
A plant source of omega‐3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO)...
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SubjectTerms Adult
Aged
biomarkers
Biomedical and Life Sciences
blood
Blood pressure
Cardiovascular disease
cardiovascular diseases
Cardiovascular Diseases - etiology
chemistry
dietary fat
docosahexaenoic acid
eicosapentaenoic acid
emerging diseases
Erythrocytes
Erythrocytes - chemistry
Esters
etiology
fatty acid composition
Fatty Acids, Omega-3
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-3 - pharmacology
Female
Genetically modified organisms
Glycine max
Health risks
Heart rate
human health
human nutrition
Humans
Laboratory tests
Life Sciences
Lipidology
Lipids
Male
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Middle Aged
Neurochemistry
Nutrition
Omega‐3 fatty acids
Original Article
pharmacology
Risk Factors
Soybean oil
Soybean Oil - pharmacology
Soybeans
Stearidonic acid
transgenic plants
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Title Stearidonic Acid-Enriched Soybean Oil Increased the Omega-3 Index, an Emerging Cardiovascular Risk Marker
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Volume 43
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