Anti-Tumor Effect of Orally Administered Spinach Glycolipid Fraction on Implanted Cancer Cells, Colon-26, in Mice

• Published in: Lipids Vol. 43; no. 8; pp. 741 - 748
• Main Authors: Maeda, Naoki, Kokai, Yasuo, Ohtani, Seiji, Sahara, Hiroeki, Kumamoto-Yonezawa, Yuko, Kuriyama, Isoko, Hada, Takahiko, Sato, Noriyuki, Yoshida, Hiromi, Mizushina, Yoshiyuki
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.08.2008; Springer-Verlag; Springer‐Verlag; Springer Nature B.V
• Subjects: adenocarcinoma; administration & dosage; Administration, Oral; animal disease models; Animals; anticarcinogenic activity; Antineoplastic Agents; Antineoplastic Agents - standards; Anti‐angiogenesis activity; Anti‐cancer cell growth activity; Anti‐tumor activity; Biomedical and Life Sciences; biosynthesis; blood supply; Body weight; Cell Line, Tumor; cell proliferation; Cell Proliferation - drug effects; chemistry; Colonic Neoplasms; Colonic Neoplasms - blood supply; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; colorectal neoplasms; drug effects; drug therapy; Female; Glycolipid; glycolipids; Glycolipids - administration & dosage; Glycolipids - biosynthesis; Glycolipids - chemistry; Glycolipids - therapeutic use; human health; Humans; Life Sciences; Lipidology; Medical Biochemistry; Medicinal Chemistry; metabolism; Mice; Mice, Inbred BALB C; Microbial Genetics and Genomics; Neoplasm Transplantation; Neurochemistry; Nutrition; oral administration; Original Article; pathology; Spinach; Spinacia oleracea; Spinacia oleracea - metabolism; therapeutic use; Tumors; Spinach; Anti-angiogenesis activity; Anti-tumor activity; Glycolipid; Anti-cancer cell growth activity

We succeeded in purifying a major glycolipid fraction from a green vegetable, spinach. This fraction consists mainly of three glycolipids: monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG), and sulfoquinovosyl diacylglycerol (SQDG). In a previous study, we found that the glyco...