[11C]Carbonyl Difluoride—a New and Highly Efficient [11C]Carbonyl Group Transfer Agent

• Published in: Angewandte Chemie International Edition Vol. 59; no. 18; pp. 7256 - 7260
• Main Authors: Jakobsson, Jimmy E., Lu, Shuiyu, Telu, Sanjay, Pike, Victor W.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 27.04.2020; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aldehydes - chemical synthesis; Aldehydes - chemistry; Carbon monoxide; Carbon Radioisotopes; carbon-11; Carbonyl compounds; carbonyl difluoride; Carbonyl groups; Carbonyls; Chemistry; Chemistry, Multidisciplinary; Difluorides; Fluorides; heterocycles; Heterocyclic Compounds - chemistry; isotopic labeling; Labeling; Molecular Structure; PET radiochemistry; Physical Sciences; Positron-Emission Tomography; Radioactive tracers; Radiochemistry; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Room temperature; Science & Technology; Substrates; carbonyl difluoride; isotopic labeling; heterocycles; C-11; MONOXIDE; MEDIATED SYNTHESIS; carbon-11; RECEPTOR; PET radiochemistry

Herein, the synthesis and use of [11C]carbonyl difluoride for labeling heterocycles with [11C]carbonyl groups in high molar activity is described. A very mild single‐pass gas‐phase conversion of [11C]carbon monoxide into [11C]carbonyl difluoride over silver(II) fluoride provides easy access to this...