Production of plasminogen activator by migrating cephalic neural crest cells

Neural crest cells migrate extensively during embryonic development and differentiate into a wide variety of cell types. Our working hypothesis is that during migration, embryonic cells secrete proteases which modify local microenvironments, thereby facilitating directed cellular movements. In this...

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Bibliographic Details
Published inThe EMBO journal Vol. 4; no. 6; pp. 1403 - 1406
Main Authors Valinsky, J.E., Le Douarin, N.M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.06.1985
Subjects
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell Movement
Cell physiology
Chick Embryo
Fibronectins - physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Molecular Weight
Neural Crest - metabolism
Plasminogen Activators - biosynthesis
Quail
Embryonic development
Vertebrata
Activator
Animal
Migration
Nervous system
Plasminogen
Aves
Neural crest
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Summary:Neural crest cells migrate extensively during embryonic development and differentiate into a wide variety of cell types. Our working hypothesis is that during migration, embryonic cells secrete proteases which modify local microenvironments, thereby facilitating directed cellular movements. In this communication, we report studies on the migration of cephalic neural crest cells in the avian embryo. We demonstrate that these cells produce high levels of the serine protease, plasminogen activator (PA), at the time of their initial migration from the neural tube and during their migration to and colonization of the developing head and neck.
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ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1985.tb03793.x