Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D610 allele

• Published in: British journal of clinical pharmacology Vol. 64; no. 4; pp. 445 - 449
• Main Authors: Cui, Yi M., Teng, Choo H., Pan, Alan X., Yuen, Eunice, Yeo, Kwee P., Zhou, Ying, Zhao, Xia, Long, Amanda J., Bangs, Mark E., Wise, Stephen D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007
• Subjects: Adrenergic Uptake Inhibitors - administration & dosage; Adrenergic Uptake Inhibitors - pharmacokinetics; Adult; Asian Continental Ancestry Group - genetics; atomoxetine; Atomoxetine Hydrochloride; China; Chinese; CYP2D6; CYP2D610; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Pharmacokinetics; Propylamines - administration & dosage; Propylamines - pharmacokinetics; China

What is already known about this subject • Atomoxetine is a cytochrome P450 2D6 (CYP2D6) substrate and its pharmacokinetics has been characterized in a predominantly White population during clinical development. • There are scant East Asian pharmacokinetic data available. • The CYP2D6*10 allele is p...