Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction

• Published in: The Journal of physiology Vol. 595; no. 8; pp. 2423 - 2430
• Main Author: Ryan, Silke
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 15.04.2017; John Wiley and Sons Inc
• Subjects: adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Blood Glucose - metabolism; Endocrine and Metabolic Conditons, Disorders and Treatments; Humans; Hypoxia; Hypoxia - metabolism; Hypoxia - pathology; Inflammation - metabolism; Inflammation - pathology; Insulin resistance; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Metabolism; Oxidative Stress - physiology; Respiratory Conditions Disorder and Diseases; Sleep Apnea, Obstructive - metabolism; Sleep Apnea, Obstructive - pathology; sleep apnoea; Symposium Review; Symposium section reviews: Physiological gases in health and disease; sleep apnoea; adipose tissue; hypoxia

Obstructive sleep apnoea (OSA) is a highly prevalent condition and recognized as a major public health burden conveying a significant risk of cardiometabolic diseases and mortality. Type 2 diabetes (T2D), insulin resistance (IR) and glucose tolerance are common in subjects with OSA and this associat...