Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic–pituitary–gonadal axis following treatment with GnRH analogues - Tornøe, Christoffer W.; Agersø, Henrik; Senderovitz, Thomas; Nielsen, Henrik A.; Madsen, Henrik; Karlsson, Mats O.; Jonsson, E. Niclas (British journal of clinical pharmacology, 2007)
Keywords: Biological and medical sciences; Dose-Response Relationship, Drug; FARMACI; Feedback, Physiological; GnRH agonist triptorelin; GnRH receptor blocker degarelix; Gonadotropin-Releasing Hormone - agonists; Gonadotropin-Releasing Hormone - pharmacokinetics; Gonadotropin-Releasing Hormone - pharmacology; Humans; Hypothalamic-pituitary-gonadal axis; Luteinizing Hormone - secretion; Male; Medical sciences; Models, Biological; NONMEM; Oligopeptides - pharmacokinetics; Oligopeptides - pharmacology; Pharmacodynamics; Pharmacology. Drug treatments; PHARMACY; Pituitary Gland; Population PK/PD modelling; Receptors, LHRH - antagonists & inhibitors; Systematic PK/PD model building framework; Testosterone - secretion; Triptorelin Pamoate - pharmacokinetics; Triptorelin Pamoate - pharmacology; Antineoplastic agent; Pharmacokinetic pharmacodynamic relationship; Population pharmacokinetics; Agonist; Endocrine gland; Decapeptide; Peptides; Central nervous system; Gonadotropin RH; Hypothalamus; Encephalon; Degarelix; hypothalamic-pituitary-gonadal axis; Pituitary gland; population PK/PD modelling; Antagonist; Hormone releasing factor; Axis; Biological receptor; Human; GnRH receptor blocker degarelix; Pharmacodynamics; Biological activity; Hypothalamic hormone; Treatment; Analog; Triptorelin; systematic PK/PD model building framework; GnRH agonist triptorelin; NONMEM