Mycobacterial antigen-induced T helper type 1 (Th1) and Th2 reactivity of peripheral blood mononuclear cells from diabetic and non-diabetic tuberculosis patients and Mycobacterium bovis bacilli Calmette-Guérin (BCG)-vaccinated healthy subjects

• Published in: Clinical and experimental immunology Vol. 158; no. 1; pp. 64 - 73
• Main Authors: Al-Attiyah, R.J, Mustafa, A.S
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.10.2009; Blackwell Publishing Ltd; Blackwell; Blackwell Science Inc
• Subjects: Adult; analysis; Analytical, structural and metabolic biochemistry; Antigens, Bacterial; Antigens, Bacterial - pharmacology; Bacterial diseases; BCG Vaccine; Biological and medical sciences; Biomarkers; Biomarkers - analysis; Cell Proliferation; Cell Proliferation - drug effects; Cells, Cultured; complications; diabetes; Diabetes Mellitus; Diabetes Mellitus - immunology; Diabetes Mellitus - microbiology; Diabetes. Impaired glucose tolerance; Disease Susceptibility; drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Immunization; immunology; Infectious diseases; Interferon-gamma; Interferon-gamma - analysis; Interleukin-10; Interleukin-10 - analysis; Interleukin-2; Interleukin-2 - analysis; Lymphotoxin-alpha; Lymphotoxin-alpha - analysis; Male; Medical sciences; microbiology; Middle Aged; mononuclear leukocytes; Mycobacterium bovis; Mycobacterium bovis - immunology; peripheral blood mononuclear cells; pharmacology; prevention & control; T-Lymphocytes; T-Lymphocytes - immunology; Th1 and Th2 cytokines; Th1 Cells; Th1 Cells - immunology; Th2 Cells; Th2 Cells - immunology; Translational Studies; tuberculosis; Tuberculosis and atypical mycobacterial infections; Tuberculosis, Pulmonary; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - prevention & control; Young Adult; Endocrinopathy; Th1 lymphocyte; Biochemistry; Mycobacterial infection; Mononuclear cell; T-Lymphocyte; Bacteria; Th2 lymphocyte; Human; peripheral blood mononuclear cells; Healthy subject; Mycobacterium bovis; Th1 and Th2 cytokines; Diabetes mellitus; BCG; Cytokine; Infection; Antigen; Blood cell; Reactivity; Tuberculosis; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Actinomycetes; diabetes
• ISSN: 0009-9104; 1365-2249; 1365-2249
• DOI: 10.1111/j.1365-2249.2009.04000.x

Patients with diabetes mellitus are more susceptible to tuberculosis (TB), and the clinical conditions of diabetic TB patients deteriorate faster than non-diabetic TB patients, but the immunological basis for this phenomenon is not understood clearly. Given the role of cell-mediated immunity (CMI) i...