Baseline and Amphetamine-Stimulated Dopamine Activity Are Related in Drug-Naïve Schizophrenic Subjects

• Published in: Biological psychiatry (1969) Vol. 65; no. 12; pp. 1091 - 1093
• Main Authors: Abi-Dargham, Anissa, van de Giessen, Elsmarieke, Slifstein, Mark, Kegeles, Lawrence S., Laruelle, Marc
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.06.2009; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; alpha-Methyltyrosine; amphetamine; Amphetamine - pharmacology; Benzamides; Biological and medical sciences; D2 receptor; dopamine; Dopamine - metabolism; Dopamine Uptake Inhibitors - pharmacology; Enzyme Inhibitors; Female; Humans; Image Processing, Computer-Assisted; Male; Medical sciences; Neostriatum - diagnostic imaging; Neostriatum - metabolism; Neuropharmacology; Pharmacology. Drug treatments; Psychiatric/Mental Health; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Pyrrolidines; Radiopharmaceuticals; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D2 - metabolism; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - metabolism; SPECT; Tomography, Emission-Computed, Single-Photon; Young Adult; α-MPT; amphetamine; D2 receptor; schizophrenia; dopamine; SPECT; α-MPT; Amphetamine derivatives; Radionuclide study; Human; Dopamine; CNS stimulant; Psychotropic; Schizophrenia; Single photon emission tomography; Catecholamine; Photon; Psychosis; D2 Dopamine receptor; Neurotransmitter; Amfetamine

Previous studies demonstrated increased striatal dopamine (DA) release after amphetamine challenge and increased striatal baseline occupancy of D2 receptors in patients with schizophrenia compared with control subjects. We report here on the relationship between these two aspects of DA release in dr...